scientific program • symposia - American Society for Reproductive ...

SCIENTIFIC PROGRAM • PLENARY SESSIONS
Wednesday, October 19, 2011 9:00 am – 9:45 am
Plenary Session 5
AMERICAN UROLOGICAL ASSOCIATION
BRUCE STEWART MEMORIAL LECTURE
THE EVOLUTION OF TREATMENT FOR TESTICULAR FAILURE:
ENDOCRINE FACTORS, GENETICS AND MICROSURGERY
Peter N. Schlegel, M.D.
Cornell University
Introducer: Edward D. Kim, M.D.
Needs Assessment and Description
Male factor fertility is an important contributor to couple’s
infertility. The treatment of testicular failure (non-obstructive
azoospermia) has become possible in the past 15 years and
is a rapidly evolving field. New insights into the genetics,
hormonal factors, and treatment options for this condition
are being rapidly gained. This is an important area for
ongoing education for all reproductive health professionals.
ADIPOSITY
Endowed by a 1987 grant from Ortho Women’s Health
Monica Skarulis, M.D.
National Institute of Diabetes and Digestive and Kidney Diseases
Introducer: R. Dale McClure, M.D.
Needs Assessment and Description
The impact of the extremes of energy balance and the
quantity of adipose tissue on metabolism and gonadal
function is of great public health importance. Conditions
of energy deficit resulting in hypothalamic amenorrhea
underscore the critical importance of adequate adipose
stores and the adipokine, leptin, for normal reproductive
function. In contrast, obesity reaching epidemic status
in adults and children in parts of the developed world is
associated with metabolic derangement and increased
morbidity and mortality across all race, ethnic and
socioeconomic strata.
Hall F 3-4
Moderator: R. Dale McClure, M.D.
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Learning Objectives
At the conclusion of this session, participants should be able
to:
1. Identify hormonal abnormalities associated with testicular
failure and potential treatments.
2. Describe the effects of genetic abnormalities
on treatment success for men with nonobstructive
azoospermia.
3. Outline treatment options, risk and benefits, including the
treatment of microdissection testicular sperm extraction.
ACGME COMPETENCY
Patient Care
TEST QUESTION:
The chance of sperm retrieval is highest for men with nonobstructive
azoospermia and:
A. AZFb deletions
B. Klinefelter syndrome
C. Maturation arrest
D. Normal follicle-stimulating hormone (FSH) levels
Wednesday, October 19, 2011 2:45 pm – 3:30 pm
Plenary Session 6
Hall F 3-4
Moderator: Linda Giudice, M.D., Ph.D.
Learning Objectives
At the conclusion of this session, participants should be able
to:
1. Describe the impact of adipose tissue on human
metabolism and reproductive function.
2. Summarize the metabolic activity of adipose tissue
and integrate lessons learned from rare disorders of leptin
deficiency.
ACGME COMPETENCY
Medical Knowledge
TEST QUESTION:
Which of the following statements correctly reflects our
understanding of ovulatory dysfunction and body fatness?
A. Energy deficit, low body fat and low leptin levels
contribute to amenorrhea only in women with eating
disorders.
B. Metabolic disturbance, insulin resistance and gonadal
dysfunction can occur in cases of leptin deficiency.
C. Most cases of extreme obesity are associated with low
leptin levels and insulin resistance.
D. Weight loss results in higher leptin levels and the return of
menstrual cycles.