scientific program • symposia - American Society for Reproductive ...

SCIENTIFIC PROGRAM • PLENARY SESSIONS
Tuesday, October 18, 2011 9:00 am – 10:30 am
Plenary Session 3
9:00 am
PROSPECTS FOR STEM CELL-BASED MEDICINE
Endowed by a 1992 grant from EMD Serono, Inc.
David T. Scadden, M.D.
Harvard University
Introducer: Linda C. Giudice, M.D., Ph.D.
Needs Assessment and Description
Stem cell biology is a rapidly changing area of basic
science that has much promise for medical care. Yet,
clinical applications remain very limited. An update on the
state of the field and directions of current research is the
substance of this presentation.
Learning Objectives
At the conclusion of this session, participants should be able
to:
1. Define two approaches beyond that of cell replacement
where stem cell biology may result in stem cell-based
medicine.
9:45 am
SOCIETY FOR THE STUDY OF REPRODUCTION EXCHANGE
SPEAKER
IN VIVO ANALYSIS OF PROGESTERONE RECEPTOR SIGNALING
IN THE ENDOMETRIUM
Francesco J. DeMayo, Ph.D.
Baylor College of Medicine
Introducer: Dolores J. Lamb, Ph.D., H.C.L.D.
Needs Assessment and Description
This session will detail the role of the progesterone receptor
in the regulation of endometrial function. This will be done
by demonstrating how mouse models can be used to
dissect the signaling pathways in the uterus and define the
interaction of the cellular compartments in the regulation of
uterine function during pregnancy and in diseased states.
Chapin Theatre
Moderator: William E. Gibbons, M.D.
59
ACGME COMPETENCY
Medical Knowledge
TEST QUESTION:
How might the ability to ”reprogram” the fate of cells result
in new drug-based and cell-based therapies?
A. By enabling the correction of genetic defects emerging
in cancer cells.
B. By creating cell “decoys” in autoimmune disease.
C. By generating cells affected by disease to serve as
targets in drug screening or as replacement cells.
Learning Objectives
At the conclusion of this session, participants should be able
to:
1. Summarize the role of the progesterone receptor in the
regulation of endometrial development, the preparation
of the endometrium for embryo attachment and support
of embryo during pregnancy.
2. Outline signaling pathways regulated by progesterone
signaling.
ACGME COMPETENCY
Medical Knowledge
TEST QUESTION:
The progesterone receptor
A. Has consistent expression in the cellular compartments
of the endometrium of the endometrium in all states of
the cycle.
B. Regulates growth factor signaling in the uterus in
preparation for embryo implantation.
C.Promotes estrogen-induced proliferation in the uterine
epithelium.