scientific program • symposia - American Society for Reproductive ...

SCIENTIFIC PROGRAM • INTERACTIVE SESSIONS
Wednesday, October 19, 2011 1:15 pm – 2:15 pm
Interactive Session
SCIENTIFIC OPPORTUNITIES IN GENERATING GAMETES FROM
INFERTILITY PATIENTS’ STEM CELLS
Presented by the Regenerative Medicine and Stem Cell Special Interest
Group
Gerald P. Schatten, Ph.D. (Chair)
University of Pittsburgh School of Medicine
Gianpiero D. Palermo, M.D., Ph.D.
Cornell University
Needs Assessment and Description
Significant progress has been made in making gametes of
varying quality in model murine systems from pluripotent
stem cells in vitro. These strategies hold promise for designing
novel contraceptives, treating infertility and restoring
fertility in children who survive cancer. While most of
these breakthroughs are highly promising from research
perspectives and typically are successful using inbred
strains of certain murine models, the gap between the
announcement of a breakthrough in the lay publications
and the actual successful translation to the clinical setting
as a responsible and reliable therapy can take decades.
Consequently, there are ongoing and urgent needs for the
ASRM community to inform colleagues about the scientific
status of stem cells and regenerative medicine, and to keep
them updated on the progress of the long process for safely
translating them to the ART for routine clinical practice.
MALE-TO-FEMALE TRANSGENDER SURGERY: TECHNIQUES,
RESULTS AND POSTOPERATIVE SEXUALITY
Joint Session presented by the Society of Reproductive Surgeons and the
Sexuality Special Interest Group
Stanton C. Honig, M.D. (Chair)
University of Connecticut School of Medicine
Jared C. Robins, M.D.
The Warren Alpert Medical School of Brown University
Christine McGinn, M.D.
Papillion Center, New Hope, Pennsylvania
Needs Assessment and Description
The reproductive endocrinologist, urologist, mental health
professional, nurse or other health care provider may be
faced with the evaluation and treatment of the transgender
patient. The evaluation of the transgender patient for
surgery is complex and generally requires that the patient
meet the World Professional Association for Transgender
Health (WPATH) Standards of Care for Gender Identity
Disorders for consideration for surgery. This includes real
life experience for 1 year, 1 year of hormone replacement
therapy and documentation of stable mental health by two
health care professionals.
The surgical approach for male-to-female treatment
is complex and usually requires orchiectomy, partial
penectomy and creation of a neoclitoris, neourethra,
neovagina (different methods will be discussed) and
creation of an external genital introitus, usually with scrotal
skin. Postoperative care will be discussed as well as the
importance of the creation of reasonable postoperative
expectations of sexuality.
Room 224 C/D
94
Learning Objectives
At the conclusion of this session, participants should be able
to:
1. Identify evidence-based developments for the use of
stem cells in the treatment of disorders related to infertility.
2. Critically appraise the state of the scientific knowledge
and the steps necessary to translate this information
regarding the generation of sperm from pluripotent stem
cells to the ART clinic.
ACGME COMPETENCY
Medical Knowledge
TEST QUESTION:
A male infertility patient has been successfully treated by
the transfer of spermatogenic stem cells into his previously
aspermic testes. Which one of the following statements is
true, given the state of the field in 2011?
A. The patient is a childhood survivor of cancer, which
rendered him infertile, but the thawing of his previously
frozen spermatogenic cells transferred after puberty,
restored his fertility.
B. The patient is a mouse.
C. The patient is a man who suffered previously from
idiopathic male infertility.
D. The patient is a man with Sertoli cell only syndrome.
Wednesday, October 19, 2011 1:15 pm – 2:15 pm
Interactive Session
Room 222
Learning Objectives
At the conclusion of this session, participants should be able
to:
1. Apply the WPATH Standards of Care for Gender Identity
Disorders.
2. List the surgical options for male-to-female transsexual
surgery.
3. Describe the potential complications of transsexual
surgery.
4. Review the surgical techniques to optimize postoperative
sexuality for the transsexual patient.
ACGME COMPETENCY
Medical Knowledge
Patient Care
TEST QUESTION:
After participating in this session, for patients considering
transsexual surgery I will do the following in my practice:
A. Use the WPATH criteria including evaluation by mental
health professionals.
B. Recommend continuing all estrogen treatment prior to
surgery.
C. Do not recommend regular vaginal dilation as part of
postoperative care.
D. Perform cystoscopy preoperatively and postoperatively
to assess voiding and urinary function.
E. Not applicable to my area of practice.