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2011 VIDEO PROGRAM Tuesday, October 18 th ASRM Video Session I 11:15 am – 1:00 pm Chapin Theatre ASRM Video Session II 4:15 pm – 6:15 pm Chapin Theatre Wednesday, October 19 th AAGL Film Festival Video Session 11:15 am – 1:00 pm Hall F 1-4 The Video Program will take place in the Orange County Convention Center. CME/CE SECTION VIDEO SESSIONS
ART, UROLOGY AND PATIENT EDUCATION Moderators: Tien Cheng “Arthur” Chang, E.L.D., Ph.D., and Marius Meintjes, D.V.M, Ph.D. V-1 11:18 AM NON-INVASIVE ASSESSMENT OF EMBRYO VIABILITY USING NOVEL AUTOMATED IMAGING TECHNOLOGY. B. Behr1, S. L. Chavez1,2,4, K. E. Loewke1,4, R. A. Reijo Pera1,2. 1Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA; 2Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA; 3Department of Mechanical Engineering, Stanford University, Stanford, CA; 4Auxogyn, Inc., Menlo Park, CA. OBJECTIVE: Recently, we demonstrated that the success or failure of human embryos in reaching the blastocyst stage can be predicted by the 4-cell stage of development with >93% sensitivity and specificity using three cell cycle imaging parameters observed prior to embryonic genome activation. Analysis of gene expression profiles indicated that embryos predicted to develop to the blastocyst stage differ in gene expression patterns from those that arrest prior to blastocyst formation, suggesting that these imaging parameters can be used as a non-invasive indicator of the underlying molecular programs. Here, we describe the development of novel time-lapse imaging technology that can be used in a conventional incubator with automatic image data processing for the prediction of embryo viability. DESIGN: In order for the time-lapse microscope to fit in a standard incubator, only the critical components of the microscope are used and designed for a short optical path. To ensure embryo light safety, the microscope is comprised of a low power LED, high sensitivity camera and darkfield illumination, the latter of which also provides high contrast between the cell membranes and cytoplasm for easy cell tracking. Extraction of the cell cycle parameters is achieved by automated software and a cell tracking algorithm, whereby each image is compared to all predicted simulations and assigned a likelihood based on similarity to achieve the best fit model. MATERIALS AND METHODS: With the development of this novel automated imaging technology and the recent identification of the three non-invasive cell cycle parameters that accurately predict blastocyst formation by the 4-cell stage, there is great potential to translate these scientific findings into IVF laboratories and improve embryo selection in combination with other criteria currently used in clinical practice. Disclosures: SC and KL are now employees of Auxogyn, Inc., which licensed intellectual property resulting from this research. BB and RRP own stock in Auxogyn. __________________________________________________________ V-2 11:25 AM A NOVEL MECHANISM IN THE DEVELOPMENT OF HUMAN EMBRYOS WITH A SINGLE PRONUCLEUS (PN) AND TWO UNEVEN PN IDENTIFIED BY TIME-LAPSE CINEMATOGRAPHY. Y. Mio, K. Yumoto, K. Iwata, A. Imajyo, Y. Iba. Reproductive Centre, Mio Fertility Clinic, Yonago, Tottori Prefecture, Japan. OBJECTIVE: Although human embryos with a single pronucleus (1PN) or uneven two pronuclei (≥10 μl of VIDEO PROGRAM Tuesday, October 18, 2011 11:15 am – 1:00 pm ASRM Video Session I Chapin Theatre 95 difference in diameter) are clinically observed on 16 to 18 hours after assisted reproductive technologies (IVF/ICSI), the detailed mechanism in the development of these embryos are still unknown. Recently, we determined a novel mechanism occurring embryos with 1PN or uneven 2PN after ICSI using time-lapse cinematography (TLC). DESIGN: The TLC of donated ICSI embryos from 109 couples was performed between April 2002 and December 2009. Each ICSI oocyte was placed in 5μl of pre-equilibrated fertilization medium within a TLC chamber on the stage of an inverted microscope. Images were captured every 2 minutes (50 ms exposure time) for approximately 40 hours. Of 109 mature oocytes that underwent ICSI, 3 of both embryos with 1PN or uneven 2PN were obtained from the TLC study. MATERIALS AND METHODS: In 3 embryos with 1PN, an unknown material was extruded next to 2nd polar body (PB) 15 minutes after the extrusion of 2nd PB and continued to exist in the perivitelline space until completion of the 1st cleavage, whereas the male PN formed in the center of the cytoplasm at 4.2 hours after ICSI. Although 3 embryos with uneven 2PN also extruded an unknown material next to 2nd PB, these embryos formed small PN-like substance (likely 3rd PB) within the unknown material in the perivitelline space. Afterward, the small PN-like substance incorporated into ooplasm followed by migration to the male pronucleus and abutment of both pronuclei. This study firstly demonstrated the novel phenomena during the miotic division in human embryos. Further TLC study will give us more information about this enigmatic phenomena. __________________________________________________________ V-3 11:32 AM TIME-LAPSE IMAGING OF TRIPRONUCLEAR EMBRYOS: MECHANISMS OF FORMATION AND ABNORMAL DEVELOPMENT. R. S. Weinerman1, M. E. Fino1, Y. Kramer1, K. C. Gunsalus2, C. McCaffrey1, N. Noyes1. 1NYU Fertility Center, New York University School of Medicine, New York, NY; 2Center for Genomics and Systems Biology, New York University, New York, NY.. OBJECTIVE: This video presents examples of abnormal embryo development in tri-pronuclear embryos originating from IVF±ICSI as viewed using time-lapse microscopy (TLM). The mechanisms of tri-pronuclear embryo formation are explained and resulting developmental phenotypes are highlighted. Specific topics reviewed include mitotic spindle formation, early embryo fragmentation, and early embryo arrest. DESIGN: Our research laboratory routinely employs TLM as a means to study early embryogenesis. Our standard clinical IVF practice is to assess all oocytes for evidence of fertilization and to document pronuclear status 18 h post-insemination by either conventional insemination or ICSI. Those zygotes containing ≥3 pronuclei are deemed unsuitable for uterine replacement and are sometimes designated for continued culture and monitoring using TLM, if the patient had signed IRB-approved informed consent for research on this material. These abnormal zygotes are placed in a stage-top incubator and viewed using highdefinition microscopy. Images are captured every 240-420
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SHOPPING When it comes to distincti
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WELCOME Roger A. Lobo, M.D. ASRM Pr
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SCIENTIFIC PROGRAM & ABSTRACT REVIE
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CONTINUING EDUCATION (CME/CE) INFOR
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SATURDAY, OCTOBER 15 2011 ASRM ANNU
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2011 ASRM ANNUAL MEETING • DAILY
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CONTRACEPTION DAY TUESDAY, OCTOBER
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American Society for Reproductive M
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POSTGRADUATE COURSE LOCATIONS COURS
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P-46 GnRH ALTERS PITUITARY ADIPONEC
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ENDOMETRIOSIS P-82 microRNA 135a EX
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P-324 SUSHI DOMAIN CONTAINING 3 (SU
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MEET AND GREET THE ASRM PRESIDENT A
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ROUNDTABLE LUNCHEONS Tuesday, Octob
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FUTURE ASRM ANNUAL MEETINGS October
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EXHIBITS ORANGE COUNTY CONVENTION C
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2011 EXHIBIT HALL FLOORPLAN • ORA
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Roche Diagnostics 2037 Rocket Medic
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SPOUSE/GUEST HOSPITALITY ROOM SATUR
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ASRM ADMINISTRATIVE STAFF 1209 Mont
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Aasted, H., O-61, P-511 Abanto, E.,
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Ben Yosef, D., P-398 Benadiva, C. A
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PROGRAM PARTICIPANTS - NON-ORAL/POS
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PROGRAM PARTICIPANTS - NON-ORAL/POS
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NOTES _____________________________
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News and Education • Access to cu
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At Your Fingertips Professional tec
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