scientific program • symposia - American Society for Reproductive ...

STEM CELLS: DERIVATION, INDUCTION AND APPLICATION
IN REPRODUCTIVE SCIENCES
Presented by the Society for Gynecologic Investigation
Lusine Aghajanova, M.D., Ph.D. (Chair)
Baylor School of Medicine
Jose Cibelli, D.V.M., Ph.D.
Michigan State University
Carlos A. Simon, M.D., Ph.D.
University of Valencia
Jonathan L. Tilly, Ph.D.
Harvard Stem Cell Institute
Caroline Gargett, Ph.D.
Monash University
SCIENTIFIC PROGRAM • SYMPOSIA
Wednesday, October 19, 2011 3:45 pm – 5:45 pm
Symposium
Room 224 A/B
Needs Assessment and Description
Physicians, residents, fellows, researchers and other
healthcare professionals need to be updated on new
advances in stem cell research (embryonic, germ cell
and adult stem cells) and their potential applications in
reproductive sciences, as well as ethical issues associated
with human stem cell research.
Learning Objectives
At the conclusion of this session, participants should be able
to:
1. Identify the types of stem cells with potential use in
reproductive medicine.
2. Debate areas of possible applications, as well as risks
and benefits associated with stem cell use in reproductive
sciences.
ENHANCING PREGNANCY RATES IN ART: CLINICAL NUANCES
Presented by the Indian Society of Assisted Reproduction
Dhiraj B. Gada, M.D. (Chair)
Gada Life Arts Center
Jaideep Malhotra, M.D.
Malhotra Nursing and Maternity Home PVT, LTD
Nandita Palshetkar, M.D.
Lilavati Hospital IVF Center
Rishma Dhillion Pai, M.D.
Lilavati Hospital & Research Centre, Mumbai, India
Needs Assessment and Description
There has been a dramatic increase in clinical pregnancy
rates in ART, yet there is much variation across the globe.
For this reason, there is a need to establish standardized
protocols based on scientific approach and evidence, so as
to give clarity and uniform outcome.
Learning Objectives
At the conclusion of this session, participants should be able
to:
1. Discuss various ovarian stimulation protocols and relate
the importance of embryo transfer technique and luteal
support and the impact on pregnancy rates.
2. Describe specific clinical skills that can potentially improve
pregnancy rates in ART.
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ACGME COMPETENCY
Medical Knowledge
TEST QUESTION:
Regarding stem-cell-based cell therapy, after participating
in this session, I will counsel patients that:
A. The use of human iPS cells produced under xeno-free
conditions for stem cell therapies will have no effect
on the regulatory burden, as they may compromise the
differentiation potential of the cells.
B. Multipotent mesenchymal stem cells have limited use
for cell replacement therapy due to their low ability to
differentiate toward multiple lineages, including
osteoblasts, myocytes, adipocytes, chondrocytes,
neurons and endometrial cells.
C. Undifferentiated cells, if getting into the appropriate
niche, will differentiate toward the desired cell type with
high likelihood of malignant potential.
D. Primordial germ cells derived from embryonic stem cell
and iPS cells offer a promise for treatment of certain types
of human infertility.
E. Postnatal mammalian ovary possesses germ cells that
can generate oocytes, but these cannot be used in
women with premature ovarian failure or aging women.
F. Not applicable to my area of practice.
Wednesday, October 19, 2011 5:45 pm – 6:15 pm
Symposium
Room 224 E/F
ACGME COMPETENCY
Medical Knowledge
Patient Care
TEST QUESTION:
After participating in this session, I will do the following in my
practice.
A. Use mild stimulation protocols for all patients.
B. Use the agonist for all ART stimulation cycles except for
poor responders.
C. Perform ET using ultrasound guidance.
D. Transfer three embryos for all patients on day 3.
E. Not prescribe estrogen during the luteal phase.
F. Never use hCG for luteal support.
G. Use adjuvants such as sildenafil/aspirin/steroids during
luteal phase.
H. Not applicable to my area of practice.