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P-387 23-CHROMOSOME SINGLE NUCLEOTIDE
POLYMORPHISM (SNP) MICROARRAY PREIMPLANTATION
GENETIC SCREENING (PGS) ON BLASTOCYSTS, VERSUS DAY-
3 EMBRYOS, RESULTS IN SIGNIFICANTLY HIGHER CLINICAL
PREGNANCY RATES.
A. T. Benner 1 , P. R. Brezina 2 , L. Du 1 , C. Chipko 3 , M. Gunn 1 , W. G.
Kearns 4 . 1 Genetics, Center for Preimplantation Genetics, LabCorp,
Rockville, MD; 2 Gynecology and Obstetrics, Johns Hopkins Medical
Institutions, Baltimore, MD; 3 Medical College of Virginia, Richmond,
VA; 4 Gynecology and Obstetrics, Genetics, Johns Hopkins Medical
Institutions, Center for Preimplantation Genetics, LabCorp, Rockville,
MD.
P-388 ABSTRACT WITHDRAWN.
P-389 THE RATE OF DE NOVO AND INHERITED ANEUPLOIDY
AS DETERMINED BY 23-CHROMOSOME SINGLE NUCLEOTIDE
POLYMORPHISM MICROARRAY (SNP) IN EMBRYOS
GENERATED FROM PARENTS WITH KNOWN CHROMOSOMAL
TRANSLOCATIONS.
L. Du 1 , P. R. Brezina 2 , A. T. Benner 1 , B. B. Swelstad 2 , M. Gunn 1 , W. G.
Kearns 3 . 1 Genetics, Center for Preimplantation Genetics, LabCorp,
Rockville, MD; 2 Gynecology and Obstetrics, Johns Hopkins Medical
Institutions, Baltimore, MD; 3 Gynecology and Obstetrics, Genetics,
Johns Hopkins Medical Institutions, Center for Preimplantation
Genetics, LabCorp, Rockville, MD.
P-390 TROPHECTODERM BIOPSY FOR SINGLE-GENE
DISORDER PREIMPLANTATION GENETIC DIAGNOSIS (PGD)
IS SIGNIFICANTLY MORE RELIABLE THAN DAY 3 BLASTOMERE
BIOPSY.
E. J. Forman 1,2 , K. M. Ferry 1 , N.-A. Gueye 2 , R. D. Smith 3 , J. Stevens 3 , R.
T. Scott, Jr. 1,2 . 1 Reproductive Endocrinology & Infertility, Reproductive
Medicine Associates of New Jersey, Morristown, NJ; 2 Obstetrics,
Gynecology and Reproductive Sciences, UMDNJ-Robert Wood
Johnson Medical School, New Brunswick, NJ; 3 Fertility Laboratories of
Colorado, Lone Tree, CO.
P-391 COMPARISON OF SINGLE GENE PREIMPANTATION
GENETIC DIAGNOSIS BY HOMOLOG PHASING ONLY VERSUS
PHASING PLUS DIRECT MUTATION DETECTION.
M. Rabinowitz 1 , M. Hill 1 , N. Wemmer 1 , J. Keller 1 , G. Gemelos 1 . 1 Gene
Security Network, Redwood City, CA; 2 Department of Genetics,
Stanford University School of Medicine, Stanford, CA.
P-392 PREIMPLANTATION GENETIC SCREENING USING
ARRAY CGH IMPROVES CLINICAL PREGNANCY RATES IN AMA
PATIENTS.
J. F. Cuzzi 1 , J. R. Alegretti 2 , A. Harutunian 3 , M. Hughes 3 , P. Hassun 1 .
1 Genetics, Genesis Genetics Brasil, Sao Paulo, SP, Brazil; 2 Human
Reproduction, Huntington Center of Reproductive Medicine, Sao
Paulo, SP, Brazil; 3 Genetics, Genesis Genetics Institute, Detroit, MI.
P-393 DOES BLASTOCYST STAGE CORRELATE WITH
EUPLOIDY?
B. Hodes-Wertz, A. Adler, C. Mullin. NYU Fertility Center, New York
University, NY, NY.
P-394 REDUCING MULTIPLE PREGNANCY RATES IN PATIENTS
UNDER 35 YEARS OLD BY TRANSFERRING A SINGLE EMBRYO IN
A PREIMPLANTATION GENETIC DIAGNOSIS PROGRAM.
Z. Yang, S. Salem, S. Zarandy, R. D. Salem. Pacific Reproductive
Center, Torrance, CA.
P-395 EMBRYO MORPHOLOGY ON DAY 3 AND DAY
5 IS PREDICTIVE OF ARRAY COMPARATIVE GENOMIC
HYBRIDIZATION (aCGH) ANEUPLOIDY RATES WITH DAY 3
BIOPSY BUT NOT DAY 5 BIOPSY.
T. L. Stankewicz, J. Gilchrist, K. K. Hanshew, S. V. Hallowell, I. P.
Glassner, J. J. Orris. IVF, Main Line Fertility and Reproductive
Medicine, Bryn Mawr, PA.
POSTER PRESENTATIONS
160
P-396 PGD VIA ARRAY COMPARATIVE GENOME
HYBRIDIZATION (aCGH) CAN BE USED FOR ANY
TRANSLOCATION TO SIMULTANEOUSLY DETECT UNBALANCED
EMBRYOS AND ANEUPLOIDY.
P. Colls 1 , T. Escudero 1 , J. Fischer 1 , N. Cekleniak 3 , S. Munne 1 .
1 Reprogenetics LLC, Livingston, NJ; 2 New York University, New York,
NY; 3 Institute for Reproductive Medicine & Science, Livingston, NJ.
P-397 23-CHROMOSOME SINGLE NUCLEOTIDE
POLYMORPHISM (SNP) MICROARRAY DETECTS GENOMIC
ABERRATIONS THAT MAY BE MISSED BY COMPARATIVE
GENOMIC HYBRIDIZATION (CGH) ARRAYS IN
PREIMPLANTATION GENETIC SCREENING (PGS).
EA. Siegel 1 , P. R. Brezina 2 , A. T. Benner 3 , L. Du 3 , M. Gunn 3 , W. G.
Kearns 4 . 1 Medical College of Virginia, Richmond, VA; 2 Gynecology
and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD;
1 Genetics, Center for Preimplantation Genetics, LabCorp, Rockville,
MD; 4 Gynecology and Obstetrics, Genetics, Johns Hopkins Medical
Institutions, Center for Preimplantation Genetics, LabCorp, Rockville,
MD.
P-398 THE FEASIBILITY OF PREIMPLANTATION GENETIC
DIAGNOSIS (PGD) FOR MULTIPLE GENETIC CONDITIONS.
V. Gold 1 , S. Peleg-Schalka 1 , T. Frumkin 1 , D. Ben Yosef 1 , Y. Yaron 1,2 ,
M. Malcov 1 . 1 Racine IVF Unit, Lis Maternity Hospital, and Prenatal
Diagnosis Unit, Genetic Institute, Tel Aviv Sourasky Medical Center,
Tel Aviv, Israel; 2 Sackler Faculty of Medicine, Tel Aviv University, Tel-
Aviv, Israel.
P-399 EFFICIENCY OF GENETIC PREIMPLANTATION
DIAGNOSIS FOR 24 CHROMOSOMES BY FISH.
E. Velilla 1 , E. Toro 2 , A. Colomar 2 , S. Chamosa 2 , M. Lopez-Teijón 3 ,
S. Fernández 1 . 1 PGD Department, Center for Embryo Medicine,
Barcelona, Catalunya, Spain; 2 Reproductive Service, Institut
Marques, Barcelona, Catalunya, Spain; 3 Leonardo Marquès
Foundation, Barcelona, Catalunya, Spain.
P-400 ANEUPLOIDY RATES OF WOMEN UNDER 35 YEARS
OLD, UNDERGOING ARRAY COMPARATIVE GENOMIC
HYBRIDIZATION (aCGH) FOR THE SOLE PURPOSE OF FAMILY
BALANCING.
T. H. Taylor, J. Gilchrist, K. K. Hanshew, T. L. Stankewicz, J. J. Orris, S. H.
Anderson. IVF, Main Line Fertility and Reproductive Medicine, Bryn
Mawr, PA.
P-401 DEVELOPMENTAL ARREST OF NORMAL AND
ABNORMAL EMBRYOS USING THE NEW PREIMPLANTATION
GENETIC SCREENING METHODS OF aCGH OR SNP.
U. A. Kayisli, I. Bozkurt, M. Frank, P. Patrizio. Yale Fertility Center, Dept
of Obstetrics, Gynecology and Reproductive Sciences Yale School
of Medicine, New Haven, CT.
P-402 IMPROVED FIXATION TECHNIQUE REDUCES TIME
CONSUMING AND INCREASES FISH EFFICIENCY.
Y. Ren, X. Zhang, L. Li, W. Wang. The Reproductive Medicine
Research Center, The 1st Hospital of Lanzhou University, Lanzhou,
Gansu Province, China.
P-403 REPEAT CCS CYCLES WILL TYPICALLY RESULT IN
SOME EUPLOID BLASTOCYSTS FOR TRANSFER IN WOMEN OF
ADVANCED MATERNAL AGE.
J. Stevens1 , R. Loper1 , H. Buttermore1 , E. S. Surrey2 , M. Katz-Jaffe2 ,
W. Schoolcraft2 . 1Fertility Laboratories of Colorado, Lone Tree, CO;
2Colorado Center for Reproductive Medicine, Lone Tree, CO.
P-404 IMPACT OF FISH AND 24 CHROMOSOME PGS ON
DONOR OOCYTE PREGNANCY RATE.
B. Behr, R. Ross, D. Batzofin, S. Wang, D. Smotrich. La Jolla IVF, La
Jolla, CA.
P-405 THE ROLE OF EMBRYONIC STAGE AT BIOPSY AND
UTERINE RECEPTIVITY AT TRANSFER IN THE CLINICAL OUTCOME
OF PREIMPLANTATION GENETIC SCREENING.
K. A. Ketterson1,3 , T. Otani2 , M. Mizuike2 , M. Roche2 , P. Colls3 . 1Tyho- Galileo Research Laboratories, Livingston, NJ; 2Reprogenetics- Japan, Nada, Kobe, Japan; 3Reprogenetics, Livingston, NJ.