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WNU-Summer Institute 2012 Christ Ch
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FIRST PART Epistemology: Radiation
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Radioactive substance (radioactivit
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Absorbed dose, D (gray or rad) Radi
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Activity (Bq) Fluence (cm-2 Fluence
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Natural Cosmic Cosmic rays Terrestr
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OSU, Stillwater, OK, USA, February
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Medical sources
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Annual average per-caput dose (in m
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Military activities 20
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Annual effective dose (mSv) Doses d
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Global average levels Natural sourc
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Annual effective dose (mSv) 6 5 4 3
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Annual per caput dose (mSv) for USA
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(3) Recent Developments on the epis
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26 July, 2012 WNU-Summer Institute
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26 July, 2012 Radiation harm to DNA
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Many other mutations occur due to D
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26 July, 2012 0.5 Mev WNU-Summer I
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26 July, 2012 Chromosomes deletions
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26 July, 2012 Chromosomal aberratio
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26 July, 2012 Probability of mutati
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26 July, 2012 First possible outcom
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26 July, 2012 Cell killingat around
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26 July, 2012 Third possible outcom
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26 July, 2012 Altered process WNU-S
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26 July, 2012 Stochastic effects Ca
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Radiation mutates DNA 26 July, 2012
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26 July, 2012 Radioepidemiology (Ep
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26 July, 2012 Difficult to assess!
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26 July, 2012 The radium dial paint
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26 July, 2012 ..the Mayak cohort of
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…all these victims of radiation e
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Solid Cancer Mortality 47 years of
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26 July, 2012 Hereditable Effects W
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The risk is so low that the estimat
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26 July, 2012 Antenatal Effects WNU
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26 July, 2012 1000mSv = IQ WNU-Summ
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Latest news 89
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Likelihood of health effects 100% (
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Likelihood of health effects 100% (
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26 July, 2012 Take away points WNU-
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Dose Very low dose: about 10 mSv or
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Remember! 1. Radiation exposure at
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Additional information to the FIRST
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Physics and chemistry Biology 10 -1
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New UNSCEAR’s assessments Epidem
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26 July, 2012 Chernobyl workers,
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26 July, 2012 Adaptive Response + M
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The role of apoptosis (cell killing
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26 July, 2012 Genomic instability
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Challenge to the paradigm Mutation
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Bystander effects The so-called “
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26 July, 2012 Signals via intercell
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26 July, 2012 WNU-Summer Institute
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26 July, 2012 Effects in another or
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Does radiation exposure affect the
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(1) The International Organizations
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UNSCEAR 26 July, 2012 WNU-Summer In
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Member States on UNSCEAR Argentina
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ICRP 26 July, 2012 WNU-Summer Insti
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agonzalez@arn.gob.ar 26 July, 2012
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Epilogue Policy Implications: plaus
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Certainty (100%) 26 July, 2012 Like
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Certainty (100%) 26 July, 2012 Like
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26 July, 2012 ICRP Publication 99 L
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Uncertainty distribution for excess
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26 July, 2012 Cumulative probabilit
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26 July, 2012 … Namely … …ICR
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Likelihood of radiation health effe
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26 July, 2012 Epistemological limit
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26 July, 2012 Difficult to detect!
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Epidemiological limit Operating alg
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Dose (mSv ( mSv) 10 2 10 1 10 -0 10
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Natural Background Chernobyl for li
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Dose (mSv ( mSv) 10 2 10 1 10 -0 10
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Thyroid cancer in children in Belar
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Dose (mSv ( mSv) 10 2 10 1 10 -0 Li
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Certainty (100%) 26 July, 2012 Like
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Take away points 1. It is plausible