ischaemic preconditioning of the human heart. - Leicester Research ...

connection, it is worth noting that Garlid et al [refs] found that diazoxide was around
2000-fold more potent at opening mitoK.. x-, -p than cardiac sarcolemmal K.
%-, 1, channels.
Figure 4.8 shows the results of MTT reduction. In essence, it reveals a mirror image of
the results with CK leakage in the aerobic control, ischernia alone and preconditioning
groups. Thus, ischemia alone caused a five-fold decrease in MTT reduction values to
those seen in the aerobic control group, and this effect was significantly prevented by
preconditioning. Both glibenclamide and 5-HD similarly abolished the protective efTect
of preconditioning. However, HMR 1883 decreased MTT reduction values to a similar
degree as that seen in PC group. Interestingly, diazoxide was as effective as
preconditioning in that the MTT reduq6on values were similar in the two groups,
however, pinacidil was less effective and the MTT reduction values in this group were
only one half of those seen in the preconditioning and diazoxide groups.
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