ischaemic preconditioning of the human heart. - Leicester Research ...

intermittent fibrillation or cold blood cardloplegia Thus, there was a significant
increase
in plasma TnT by I hr after termination of ischaemia that peaked at 4hr with
mean values still remaining elevated at 48 hr. Interestingly, preconditioning did not
alter this profile in both groups, suggesting that preconditioning conveys no benetit to
patients undergoing coronary surgery using cardiopulmonary bypass.
By contrast, as shown in Figure 7.1 C, the profiles of plasma TnT were diflerent in
patients with or without preconditioning and operated off-pump. Peak release
occurred by 8 hr after termination of ischaemia in the control group but by I hr in the
preconditioned group with a sharp decrease over the next 3 hr with mean plasma TnT
values significantly lower than in the control group. Only by the end of 48 hr TnT
levels were similar in both groups.
Figure 7.2 shows that the cumulative plasma release of TnT (I e area under the cu"'e)
was similar in the groups operated under CPB with no significant effect of
preconditioning, It also shows that TnT release was lower in patients operated without
CPB and, importantly that preconditioning in this group significantly reduced the total
TnT release by 33% when compared to the control group (2 If 01 vs 3 It 02
ng. hr/ml, p