ischaemic preconditioning of the human heart. - Leicester Research ...

More documents

Recommendations

Info

318. Van der Vusse GJ, Van der Veen FH, Flameng W, Coumans W, Gorgers M, Willems G, Suy R, de Meyer R and Reneman RS (1986). A biochemical and ultrastructural study on myocardial changes dudng aorto- coronary bypass: St. Thomas Hospital cardioplegia solution versus intermittent aortic cross-clamping at24and 250C. EurSurgReslB: 1-11. 319. Van Winkle DM, Thornton JD, Downey DM, Downey JM. (1991). The natural history of preconditioning: card ioprotection depends of duration of transient ischemia and time to subsequent ischemia. Coronafy Artefy Dis. 2: 613-619. 320. Van Winkle D, Chien G, Wolff R, Soifer B, Kuzume K and Davis R (1994). Card ioprotection provided by adenosine receptor activation is abolished by blockade of the KATP channel. Am J Physiol 266: H829-H839. 321. Van Winkle DM, Thornton J and Downey JM (1991). Cardioprotection from ischaemic preconditioning is lost following prolonged reperfusion in rabbits. Circulation 84 (SuppI 11): 432. 322. Vanverschelde J-L, Wijns W, Depre C, Essamd B, Heynddck GR, Borgers M, Bol A and Melin A (1993). Mechanisms of chronic regional post- ischaemic dysfunction in humans. New insights from the study of non- infarcted collateral-dependent myocardium. Circulation 87 : 1523-1573. 323. Vegh A, Papp JG and Parratt JR (1994). Prevention by dexamethasone of the marked antiarrhythmic effects of preconditioning induced 20 hour after rapid cardiac pacing, BrJPhannacol 113 : 1081-1082. 218
324. Walker D, Marber M, Walker J and Yellon D (1994). Preconditioning in isolated superfused rabbit papillary muscles. Am J Physiol 266 :H 1534- H 1540. 325. Walker D, Walker J, Pugsley W, Pattison C and Yellon D (1995). Preconditioning in isolated superfused human muscle. J Mofi Ce// Cardiol 27 1349-57. 326. Walker D, Walker J and Yellon D (1993). Global myocardial ischaemia protects the myocardium from subsequent regional ischaernia. Cardidscience 4: 263-6. 327. Walsh R, Borges M, Thornton J and Cohen MV (1992). Hypoxia preceeding ischaernia reduces infarction despite the lack of an intervening period of reoxygenation (abstract). Circulation 86 (Suppi 1) : 1-342. 328. Warltier D, Auchampach J and Gross G (1993). Relationship of severity of myocardial stunning to KATp channel modulation. J Cardiovasc Surg 8 (Suppi): 279-283. 329. Wayne E and Laplace L (1993). Observations on angina of effort. Clin Sci 1: 103-29. 330. Webster K, Discher D and Bishopric N (1995). Cardioprotection in an in vitro model of hypoxic preconclitioning. J Moll Ce/I Cardiol 27: 453-8. 219
Page 1 and 2:
ISCHAEMIC PRECONDITIONING OF THE HU
Page 3 and 4:
ABSTRACT Ischaemic preconditioning
Page 5 and 6:
andomised clinical study with the f
Page 7 and 8:
CHAPTERI Introduction 35 Matefials
Page 9 and 10:
Discussion 151 CHAPTER Vill Conclus
Page 11 and 12:
44 CK leakage and MTT reduction on
Page 13 and 14:
The Wellcome Trust and The British
Page 15 and 16:
Presentations International "The Ef
Page 17 and 18:
Abbreviations An attempt has been m
Page 19 and 20:
1.1 Introduction Ischaernic heart d
Page 21 and 22:
1.2 Myocardial Ischaemia Myocardial
Page 23 and 24:
hours up to several days to complet
Page 25 and 26:
phosphates and its influence on hyd
Page 27 and 28:
1.4 Myocardial Protection This refe
Page 29 and 30:
performed. This process is repeated
Page 31 and 32:
1.6 Possible Mechanisms of Ischaemi
Page 33 and 34:
kilodalton stress proteins. These p
Page 35 and 36:
and these proteins have been sugges
Page 37 and 38:
K vi-1, channels were initially fou
Page 39 and 40:
tissues the K.. %,.,, channels are
Page 41 and 42:
Subsequently, Jaburek et al 1145] i
Page 43 and 44:
venous capacitance vessels. At ther
Page 45 and 46:
preconditioning to be investigated
Page 47 and 48:
In the angioplasty model, Tomai et
Page 49 and 50:
patients were randomized into two g
Page 51 and 52:
CHAPTER 11 THE HUMAN RIGHT ATRIAL T
Page 53 and 54:
inexpensive. Briefly in this model,
Page 55 and 56:
of each ischemic period, slices wer
Page 57 and 58:
30 nini FO linlin L 60 min 120 inin
Page 59 and 60:
In Study 3 (see Figure 2.4), slices
Page 61 and 62:
D. Metabolite analysis Samples were
Page 63 and 64:
leakage is calculated as the net LD
Page 65 and 66:
B. Effect of the severity of ischae
Page 67 and 68:
2.11 DISCUSSION: The present studie
Page 69 and 70:
clearly insufficient to induce myoc
Page 71 and 72:
The present model may facilitate th
Page 73 and 74:
2.12 Conclusiow I have characterise
Page 75 and 76:
3.5 3 V 2.5 3: m Je m Z0 z 2 1.5 0.
Page 77 and 78:
(3 3 2.5 a 1.5 - -r T 0 2 0.5 0 I P
Page 79 and 80:
Q oro . 21 . 0 'a IP 10 '. R -C3 A
Page 81 and 82:
=3 0 h X CD 0 x CD :3 0 , 7, CD 0 0
Page 83 and 84:
CHAPTER III PRECONDITIONING THE HUM
Page 85 and 86:
3.2 MATERIALS AND METHODS-. 3.2.1 E
Page 87 and 88:
A117'reduction- At the end of the e
Page 89 and 90:
-4 ýi r. () .1 a 0 1 tli n F5* - C
Page 91 and 92:
v M. %; n C) .0 ý U ý ý - - - -2
Page 93 and 94:
leakage resulting from precondition
Page 95 and 96:
3.5 DISCUSSION: The present studies
Page 97 and 98:
during cardiac surgery totalling 10
Page 99 and 100:
different. The cellular mechanisms
Page 101 and 102:
cn Je 8 7 6 5 4 1 0 0.8 0.7 0.6 0.5
Page 103 and 104:
8 6 C) 2 0.7 0.6 Q) 0.5 0) E 25 0.4
Page 105 and 106:
6 5 CY) ,u3 CF) m -ýe m 2 1 0 -0.8
Page 107 and 108:
CHAPTERIV THE ROLE OF THE KATPCHANN
Page 109 and 110:
It has been reported that K.. %-I-p
Page 111 and 112:
0 a- I a 3 I cr =r Cl. 2 qQ 0'-ý 0
Page 113 and 114:
Figure 4.7 shows that ischaemia alo
Page 115 and 116:
Figure 4.2 Dosc-responsc experiment
Page 117 and 118:
Figure 4.4 Dose-response experiment
Page 119 and 120:
Figure 4.6 Dosc-response experiment
Page 121 and 122:
1 0.9 -ý 0.8 0.7 E 0.6 0.5 0.4 0.2
Page 123 and 124:
activity, and showed that diazoxide
Page 125 and 126:
Furthermore, Van den Hoek et al [3
Page 127 and 128:
mechanism by which the opening of m
Page 129 and 130:
5.1 INTRODUCTION: Within the enormo
Page 131 and 132:
5.2 MATERIALS AND METHODS: 5.2.1 Ex
Page 133 and 134:
M77'rechiction: At the end of the e
Page 135 and 136:
oc 0 0 cr F; * 10 eb I ý; o I 5 0
Page 137 and 138:
Pages missing original in the
Page 139 and 140:
esulted in a decrease of CK leakage
Page 141 and 142:
are on long-term hypoglycaernics or
Page 143 and 144:
absence of uniformity of expeniment
Page 145 and 146:
5.7 Conclusion Preconditioning is a
Page 147 and 148:
0.9 0.8 07 m 0.6 E -0 0t 4 0.3 02 0
Page 149 and 150:
-0 1.2 1 &8 0.6 04 0.2 o Aerobic Is
Page 151 and 152:
6.1 INTRODUCIFION' Life expectancv
Page 153 and 154:
(MI-T) to blue t'()rmazan product C
Page 155 and 156:
The demonstration that ischaemic in
Page 157 and 158:
Table 61 Patients' demographic and
Page 159 and 160:
Nure 6,1: Creatine Kinase (CK) leak
Page 161 and 162:
CHAPTER VII IN VIVO STUDIES ON T"E
Page 163 and 164:
The apparent discrepancy bet,.,,, e
Page 165 and 166:
In the off-pump group, coronary byp
Page 167 and 168:
eduction as described in section 3.
Page 169 and 170:
7.4.2 In vitro studies Figures 7.3A
Page 171 and 172:
preconditioning stimulus in man is
Page 173 and 174:
myocardium. Several investigators [
Page 175 and 176:
Table 7.2 - Patients haemod-v-namic
Page 177 and 178:
(0 -I 3 CD CD CD 1 3 0 :3 0 0 =r w
Page 179 and 180:
0 co t X 3 co 0 0 Cumulative Releas
Page 181 and 182:
-& a) c) UT 0 =r w CD 3 CD 0 1ý (a
Page 183 and 184:
When ischaernic preconditioning was
Page 185 and 186: evidence tbr the involvement ot'PKC
Page 187 and 188: institution o fcardiopu Imo nary by
Page 189 and 190: Biblioqraphv 1. Abete P, Ferrara N,
Page 191 and 192: 14. Auchampach J, Cavero, I and Gro
Page 193 and 194: 27. Becker LB, Van den Hoek TLV, Sh
Page 195 and 196: 41. Bums PG, Krunkenkamp IB, Calder
Page 197 and 198: 55. Cohen G, Shirai T, Weisel RD, e
Page 199 and 200: 69. Currie RW and White FP (1983).
Page 201 and 202: 83. Downey JM, Liu GS and Thornton
Page 203 and 204: 97. Ganote C, Armstrong S and Downe
Page 205 and 206: 110. Grover GJ, D'Alonzo A, Hess T,
Page 207 and 208: 122. Hamilton T and Weston A (1989)
Page 209 and 210: 137. Hu H, Sato T, Seharaseyon J, L
Page 211 and 212: 151. Jennings R, Steenbergen C, Kin
Page 213 and 214: 164. Kelpzig H, Kobert G, Mafter C,
Page 215 and 216: 178. Lamping K, Christensen C, Pelc
Page 217 and 218: 192. Liu GS, Thornton J, Van Winkle
Page 219 and 220: 206. Maulik N, Yoshida T, Das DK. (
Page 221 and 222: 219. Miyawaki H, Zhou X, Ashraf, M.
Page 223 and 224: 233. Okazaki Y, Kodama K, Sato H, K
Page 225 and 226: 248. Pryzlenk K, Li G, Whittaker P
Page 227 and 228: 260. Saito S, Tamura Y, Moriuchi M,
Page 229 and 230: 274. Schulz R, Post H, Valhaus C, e
Page 231 and 232: 288. Stewart JR, Blackwell WH, Crut
Page 233 and 234: 300. Tani M, Suganuma Y, Hasegawa H
Page 235: 312. Tosaki A, Engelman DT, Engelma
Page 239 and 240: 337. Yamashita N, Nishida M, Hoshid
Page 241 and 242: 351. Zhang JG, Lindup WE. (1993). R
Page 243 and 244: 444 J. -G. Zhang and others are dif
Page 245 and 246: 446 J. -G. Zhang and others Assessm
Page 247 and 248: 448 J. -G. Zhang and others 0.9 0.8
Page 249 and 250: 450 J. -G. Zhang and others C E 07
Page 251 and 252: 4S2 J. -G. Zhang and othen effects
Page 253 and 254: ELSEVIER Abstract Cardiovascular Re
Page 255 and 256: 936 S. Ghosh et al. / Cardiovascula
Page 257 and 258: 938 S. Ghosh et al. / Cardiovascula
Page 259 and 260: 940 S. Ghosh et al. [41 Goto M, Liu
Page 261 and 262: 712 0" et &L h wcomMe geg in Obwa»
Page 263 and 264: 714 Gbosb ot aL hmoo dmoWmbDbsnedH
Page 265 and 266: 716 chmä et aL Pi unamOso äu In O
Page 267: 718 ehe* et &L ditioning in the hum
show all

ischaemic preconditioning of the human heart. - Leicester Research ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?