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groupe de recherche sur le système nerveux central - GRSNC

groupe de recherche sur le système nerveux central - GRSNC

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BOEHM, JannicBOEHM, JannicTél. (514) 343-6370 PhysiologieUniversité <strong>de</strong> MontréalC.P. 6128, Succ. Centre-vil<strong>le</strong>, MontréalFax (514) 343-7072 Canada H3C 3J7URL site WWW: http://www.physio.umontreal.ca/jannic_boehm/lab/bienvenue_welcome.htmlE-Mail: jannic.boehm@umontreal.caURL personnel CV:Statut universitaire / University statusChercheur adjointPhysiologieFaculté <strong>de</strong> mé<strong>de</strong>cineUniversité <strong>de</strong> MontréalAppartenance à d'autres <strong>groupe</strong>s / Affiliation with other groupsGroupe <strong>de</strong> <strong>recherche</strong> <strong>sur</strong> <strong>le</strong> système <strong>nerveux</strong> <strong>central</strong> (<strong>GRSNC</strong>) - FRSQFormation / TrainingDiploma in Biology, University Wuerzburg, Al<strong>le</strong>magne, 1996Ph.D., University Ulm, Al<strong>le</strong>magne, 2001Postdoctoral, Cold Spring Harbor Laboratory, Neuroscience, 2002-2007Orientations <strong>de</strong> la <strong>recherche</strong>•Les changements dans la plasticité synaptique associés à la maladie d'Alzheimer•La régulation du transport <strong>de</strong>s ARNm et <strong>de</strong> la traduction <strong>de</strong> protéines pendant la plasticité synaptiquePrincipaux projets en cours:•Effets <strong>de</strong>s oligomères solub<strong>le</strong>s d'amyloï<strong>de</strong>-bêtas <strong>sur</strong> la transmission synaptique.•Participation <strong>de</strong>s miRNAs dans la plasticité synaptique.Research orientations•Changes in synaptic plasticity during Alzheimer’s disease•Regulation of mRNA transport and protein translation during synaptic plasticityCurrent Research Projects:•Effects of solub<strong>le</strong> amyloid-beta oligomers on synaptic transmission.•Involvement of miRNAs in synaptic plasticity.Publications choisies/Se<strong>le</strong>cted publicationsJannic Boehm, Yunsheng He, Axel Greiner, Louis Staudt and Thomas Wirth. Regulation of BOB.1/OBF.1 stability by SIAH. EMBO J. 2001 Aug 1;20(15):4153-62.Jannic Boehm, Myoung-Goo Kang, Jose Esteban, Richard L. Huganir and Roberto Malinow. Synaptic Incorporation of AMPA Receptors Dur-ing LTP is Control<strong>le</strong>d by a NovelPKC Phosphorylation Site on GluR1. Neuron. 2006 Jul 20;51(2):213-25.Jannic Boehm, Ingrid Ehrlich, He<strong>le</strong>n Hsieh and Roberto Malinow. Subt<strong>le</strong> modifications of GluR1 cytoplasmic tail differentially affect synaptic plasticity. Learn Mem. 2006 Sep-Oct;13(5):562-5.He<strong>le</strong>n Hsieh, Jannic Boehm, Chihiro Sato, Takeshi Iwatsubo, Taisuke Tomita, Sangram Sisodia and Roberto Malinow. AMPA-R Removal Un<strong>de</strong>rlies A-induced SynapticDepression and Dendritic Spine Loss. Neuron. 2006 Dec 7;52(5):831-43.Page 28

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