groupe de recherche sur le système nerveux central - GRSNC

SOSSIN, WayneTél. (514) 398-1486 Neurologie et neurochirurgieInstitut neurologique de Montréal3801 rue Université, Montréal (Québec)Fax (514) 398-8106 Canada H3A 2B4URL site WWW: http://www.mni.mcgill.ca/cbct/waynes/index.htmlE-Mail: wayne.sossin@mcgill.ca URL personnel CV:Statut universitaire / University statusProfesseur titulaireNeurologie et neurochirurgieFaculté de médecineUniversité McGillAppartenance à d'autres groupes / Affiliation with other groupsProfessor, Department of Anatomy & Cell Biology, McGill UniversityMember, Department of Psychology, McGill UniversityMembre associé, Département de physiologie, Université de MontréalMembre du Groupe de recherche sur le système nerveux central (GRSNC) du FRSQFormation / TrainingS.B., Massachussetts Institute of Technology, Biology, 1984S.B., Massachussetts Institute of Technology, Computer Science, 1984Ph.D., Stanford University, Biological Sciences, 1989Orientations de la recherche• Méchanismes biochimiques de l’emprunte synaptique• Régulation de la libération des neurotransmetteurs• Protéine kinase C et mémoirePrincipaux projets en cours:• Protéomics et RNA granulaire• La voie sensible à la rapamycine comme marqueur synaptique• Un transfer vers la traduction indépendante de cap dans la mémoire intermédiaire• Régulation de PKC dans le système nerveux central• Epissage alternatif de synaptotagmineResearch orientations• Biochemical mechanisms of synaptic tagging• Regulation of transmitter release• Protein kinase C and memoryCurrent research projects:• Proteomics of the RNA granule• The rapamycin-sensitive pathway as a synaptic tag• A switch to cap-independent translation in intermediate memory• Regulation of PKC in the nervous system• Alternative splicing of synaptotagminSOSSIN, WaynePublications choisies/Selected publicationsGobert D, Topolnik L, Azzil M, Huang L, Badeaux F, DesGroseillers L, Sossin WS and Lacaille L-C (2007) Forskolin induction of late-LTP and up-regulation of 5’TOP nRNAstranslation via mTOR in hippocampal pyramidal cells. J Neurochem 106:1160-1174.Lebeau G, Maher-Laporte M, Topolnik L Laurent CE, Sossin WS, DesGroseillers L and Lacaille J-C (2008) Staufen1 regulation of protein synthesis-dependent long-termpotentiation and synaptic function in hippocampal pyramidal cells. Mol. Cell. Biol. 28:2896-2907.Sossin WS (2008) Defining memories by their distinct molecular traces. Trends Neurosci. 31:170-175.Nagakura I, Ormond J, Sossin WS (2008) Mechanisms regulating ApTrkl, a Trk-like receptor in Aplysia sensory neurons. J. Neurosci. Res. 86:2876-2883.Abi Farah C, Nagakura, I. Weatherill D, Fan X, and Sossin WS (2008) A physiological role for phosphatidic acid in the translocation of the novel protein kinase C APLII in Aplysianeurons. Mol. Cell Biol. 28:4719-4733.Costa-Mattioli M, Sossin WS, Klann E, Sonenberg N. (2009) Translational control of long-lasting synaptic plasticity and memory Neuron 15:10-26Miller LC, Blandford V, McAdam R, Sanchez-Carbente MR, Badeaux F, DesGroseillers L and Sossin WS. (2009) Combinations of DEAD box proteins distinguish distinct types ofRNA:protein complexes in neurons Mol Cell Neurosci 40:485-495 (Cover of Journal)Bougie JK, Lim T, Farah CA, Manjunath V, Nagakura I, Ferraro GB and Sossin WS (2009) The Atypical Protein Kinase C in Aplysia can form a protein kinasse M by cleavage. J.Neurochem 109:1129-1143Villareal,G Li, Q, Cai, D, Fink, A Lim, T Bougie J, Sossin WS and Glannzman DL. (2009) Role of Protein Kinase C in the Induction and Maintenance of Serotonin-DependentEnhancement of the Glutamate Response in Isolated Siphon Motor Neurons of Aplysia Californica. J. Neuroscience 29:5100-5107: Paper of the Week.Wang DO, Kim S, Zhao Y, Hwang H, Mioru S, Sossin WS and Martin KC (2009)Synapse- and stimulus-specific local translation during long-term neuronal plasticity Science324(5934) :1536-1540.Farah CA, Weatherill D, Dunn TW and Sossin WS (2009) PKC differentially translocates during spaced and massed training in Aplysia. J. Neurosci. 29(33) :10281-10286.Page 59