groupe de recherche sur le système nerveux central - GRSNC
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groupe de recherche sur le système nerveux central - GRSNC

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CARMANT, LionelTél. (514) 345-4931 #6106 PédiatrieHôpital Sainte-Justine3175, Côte Ste-Catherine, Montréal (Québec)Fax (514) 345-4787 Canada H3T 1C5URL site WWW:E-Mail: lionel.carmant@umontreal.ca URL personnel CV:CARMANT, LionelStatut universitaire / University statusProfesseur agrégéPédiatrieFaculté <strong>de</strong> mé<strong>de</strong>cineUniversité <strong>de</strong> MontréalAppartenance à d'autres <strong>groupe</strong>s / Affiliation with other groupsCanadian Pediatric Epi<strong>le</strong>psy NetworkRepric (Imagerie cérébra<strong>le</strong>)Membre du Centre <strong>de</strong> <strong>recherche</strong> en sciences neurologiques (CRSN)Formation / TrainingM.D., Université <strong>de</strong> Sherbrooke, 1986Rési<strong>de</strong>nce, Université <strong>de</strong> Sherbrooke, Neurologie, 1988Rési<strong>de</strong>nce, Université McGill, Neuropédiatrie, 1990Fellowship, Université Harvard, Épi<strong>le</strong>psie pédiatrique, 1992Orientations <strong>de</strong> la <strong>recherche</strong>• Mécanismes d'épi<strong>le</strong>ptogénèse• Neuroprotection et épi<strong>le</strong>psie• Modè<strong>le</strong> animaux: aci<strong>de</strong> kainique, convulsions fébri<strong>le</strong>s• É<strong>le</strong>ctrophysiologie: EEg in vivo, patch clamp in vitro• Immunohistochimie• Comportement Morris water mazePrincipaux projets en cours:•Le rô<strong>le</strong> <strong>de</strong>s convulsions fébri<strong>le</strong>s prolongées chez <strong>le</strong>s enfants souffrant d'épi<strong>le</strong>psie du lobe temporal•Va<strong>le</strong>ur diag. <strong>de</strong> la spectroscopie proche infrarouge (SPIR) dans l'investigation <strong>de</strong>s patients avec épi<strong>le</strong>psie partiel<strong>le</strong> néocortica<strong>le</strong> nonlésionnel<strong>le</strong>réfractaire candidates à un traitement chirurgical; FIN avril 2011•Registre <strong>de</strong> SUDEP dans l’enfant; FIN juin 2010•Renouvel<strong>le</strong>ment, Le Groupe <strong>de</strong> Recherche <strong>sur</strong> <strong>le</strong> Système Nerveux Central (<strong>GRSNC</strong>) comme <strong>groupe</strong> du FRSQ; FIN juin 2010Research orientations• Epi<strong>le</strong>ptogenesis mechanisms• Neuroprotection and epi<strong>le</strong>psy• Animal mo<strong>de</strong>ls: kainic acid, febri<strong>le</strong> seizures• E<strong>le</strong>ctrophysiology: In vivo EEG, in vitro patch clamp• Immunohistochemistry• Morris water maze behaviourCurrent research projectsI:• Epi<strong>le</strong>ptogenic ro<strong>le</strong> of prolonged febri<strong>le</strong> seizures in children who <strong>de</strong>velop temporal lobe epi<strong>le</strong>psy• Value diag. of near infrared spectroscopy (NIRS) in the investigation of patients with neocortical partial epi<strong>le</strong>psy refractory non<strong>le</strong>sionalcandidates for <strong>sur</strong>gical treatment; END April 2011• Registry of SUDEP in Children; END June 2010• Renewal, The Group for Research on Central Nervous System (<strong>GRSNC</strong>) as group FRSQ; END June 2010Publications choisies/Se<strong>le</strong>cted publicationsBocti C*, Robitail<strong>le</strong> Y, Diadori P, Lortie A, Mercier C, Bouthillier A, Carmant L. The pathological basis of temporal epi<strong>le</strong>psy in childhood. Neurology 2003;60: 191-195.Scant<strong>le</strong>bury MH*, Ouel<strong>le</strong>t PL*, Psarropoulou C, Carmant L. Freeze <strong>le</strong>sion-induced focal cortical dysplasia predisposes to atypical hyperthermic seizures in the immature rat.Epi<strong>le</strong>psia 2004;45:592-600.Scant<strong>le</strong>bury, MH*, Gibbs SA*, Foadjo B*, Lema P, Psarropoulou C, Carmant L. Febri<strong>le</strong> seizures in the predisposed brain: a new mo<strong>de</strong>l of temporal lobe epi<strong>le</strong>psy. Annals ofNeurology 2005; 58(1):41-9.Gibbs SA*, Scant<strong>le</strong>bury MH*, Lema P**, Essouoma JB*, Descarries L, Carmant L. Hippocampal atrophy and abnormal brain <strong>de</strong>velopment following a prolonged hyperthermicseizure in the immature rat with a focal neocortical <strong>le</strong>sion. Neurobiol Dis. 2008 Oct;32(1):176-82. Epub 2008 Jul 18.Lévesque M, Langlois JM, Lema P, Courtemanche R, Bilo<strong>de</strong>au GA, Carmant L. Synchronized gamma oscillations (30-50 Hz) in the amygdalo-hippocampal network in relationwith seizure propagation and severity. Neurobiol Dis. 2009;35: 209-218.Page 29

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