groupe de recherche sur le système nerveux central - GRSNC

FERNANDES, KarlTél. (514) 343-5617 Pathologie et biologie cellulaireUniversité de MontréalC.P. 6128, Succ. Centre-ville, MontréalFax (514) 343-5755 Canada H3C 3J7URL site WWW: http://www.patho.umontreal.ca/kfernandesbc.htmE-Mail: karl.jl.fernandes@umontreal.ca URL personnel CV:Statut universitaire / University statusChercheur adjointPathologie et biologie cellulaireFaculté de médecineUniversité de MontréalAppartenance à d'autres groupes / Affiliation with other groupsMembre du Centre d’excellence en neuromics de l’Université de Montréal (CENUM)Membre du Groupe de recherche sur le système nerveux central (GRSNC) du FRSQFormation / TrainingB.Sc., Université d'Ottawa, Physiologie, Biochimie, 1990-1994Ph.D., Université de Colombie-Britannique, Vancouver, Zoologie (Neuroscience), 1995-2000Orientations de la recherche•La neurobiologie des cellules souchesPrincipaux projets en cours:•Cellules souches du cerveau : régulation pendant le vieillissement et la maladie d’Alzheimer.•Cellules souches de l’hippocampe : régulation par l’exercice physique et stimulation cognitive.•Cellules souches de la moelle épinière : identification, caractérisation, et réponses au traumatismes/maladies.Research orientations•Stem cell neurobiologyCurrent Research Projects:•Brain neural stem cells: regulation during aging and Alzheimer’s Disease•Neural stem cells of the hippocampus: regulation by physical exercise and cognitive stimulation•Neural stem cells of the spinal cord: identification, characterization, and responses to injury/diseasesFERNANDES, KarlPublications choisies/Selected publicationsToma JG, Akhavan M*, Fernandes KJL*, Barnabe-Heider F, Sadikot A, Kaplan DR, Miller FD (2001) Isolation of multi-potent adult stem cells from the dermis of mammalian skin.Nat Cell Biol 3 (9):778-784. *equal contributionsFernandes KJL*, McKenzie IA*, Mill P, Smith K, Akhavan M, Barnabé-Heider F, Biernaski J, Junek A, Kobayashi NR, Toma JG, Kaplan DR, Labosky PA, Rafuse V, Hui CC,Miller FD (2004). A dermal niche for multipotent adult skin-derived precursor cells. Nat Cell Biol 6(11):1082-1093 *equal contributionsNadeau S*, Hein P*, Fernandes KJL, Peterson AC, Miller FD (2005). A transcriptional role for C/EBP beta in the neuronal response to axonal injury. Mol Cell Neurosci 29(4):525-535Barnabé-Heider F, Wasylnka JA, Fernandes KJL, Porsche C, Sendtner M, Kaplan DR, Miller FD (2005). Evidence that embryonic neurons regulate the onset of corticalgliogenesis via cardiotrophin-1. Neuron 48:253-265.Fernandes KJL*, Kobayashi NR*, Gallagher CJ, Barnabé-Heider F, Aumont A, Kaplan DR, Miller FD (2006). Analysis of the neurogenic potential of multipotent Skin-derivedPrecursors. Exp Neurol 2006. 201(1): p. 32-48. *equal contributionsFernandes KJL, Toma JG, Miller FD (2008). Skin-derived Precursors: adult neural crest-related precursors with multilineage differentiation potential. Philos Trans R Soc Lond BBiol Sci. 363(1489):185-198.El-Helou V, Beguin PC, Assimakopoulos J, Clement R, Gosselin H, Brugada R, Aumont A, Biernaskie J, Villeneuve L, Leung TK, Fernandes KJ, Calderone A (2008). The ratheart contains a neural stem cell population; role in sympathetic sprouting and angiogenesis. J Mol Cell Cardiol 45(5):694-702.Fernandes KJ, Miller FD (2009). Isolation, expansion, and differentiation of mouse skin-derived precursors. Methods Mol Biol 482:159-70.Bednarczyk MR, Aumont A, Décary S, Bergeron R, Fernandes KJL (2009). Prolonged voluntary wheel-running stimulates neural precursors in the hippocampus and forebrain ofadult CD1 mice. Hippocampus 19(10):913-27.Hamilton LK, Truong MK, Bednarczyk MR, Aumong A, Fernandes KJL (in press). Cellular organization of the central canal ependymal zone, a niche of latent neural stem cells inthe adult mammalian spinal cord. Neuroscience (Epub ahead of print).Page 42