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groupe de recherche sur le système nerveux central - GRSNC

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DANCAUSE, NumaTél. (514) 343-6317 PhysiologieUniversité <strong>de</strong> MontréalC.P. 6128, Montréal (Québec)Fax (514) 343-2111 Canada H3C 3J7URL site WWW:E-Mail: numa.dancause@umontreal.ca URL personnel CV:DANCAUSE, NumaStatut universitaire / University statusChercheur adjointPhysiologieFaculté <strong>de</strong> mé<strong>de</strong>cineUniversité <strong>de</strong> MontréalFormation / TrainingB.Sc., Université <strong>de</strong> Montréal, Physiothérapie, 1993-1996M.Sc., Université <strong>de</strong> Montréal, Sciences neurologiques, 1998-2000Ph.D., Kansas University Medical Center, Mo<strong>le</strong>cular and Integrative Physiology, 2000-2005Postdoc, Kansas University Medical Center, Mo<strong>le</strong>cular and Integrative Physiology, 2005-2006Postdoc, University of Rochester Medical Center, Neurology, 2006-2009Orientations <strong>de</strong> la <strong>recherche</strong>• Étu<strong>de</strong> <strong>de</strong> la plasticité cortica<strong>le</strong> supportant la récupération motrice suivant l'acci<strong>de</strong>nt cérébrovasculaire• Étu<strong>de</strong> <strong>de</strong> la plasticité <strong>de</strong>s voies corticospina<strong>le</strong>s supportant la récupération motrice suivant l'acci<strong>de</strong>nt cérébrovasculaire• Étu<strong>de</strong> <strong>de</strong> l'impact <strong>de</strong> la réadaptation <strong>sur</strong> la plasticité neurona<strong>le</strong> et récupération motrice suivant l'acci<strong>de</strong>nt cérébrovasculairePrincipaux projets en cours:• Les changements immédiats <strong>de</strong> l'activité neurona<strong>le</strong> du cortex contralésionel suivant l'inactivation du cortex moteur primaire• La réorganisation progressive <strong>de</strong> l'activité neurona<strong>le</strong> du cortex contralésionel suivant une lésion du cortex moteur primaire• La réorganisation <strong>de</strong>s interactions et <strong>de</strong>s connexions interhémisphériques suivant une lésion du cortex moteur primaireResearch orientations• Study of cortical plasticity supporting recovery following a stroke• Study of corticospinal plasticity supporting recovery following a stroke• Study of the effect of rehabilitative approaches on neuronal plasticity and motor recovery following a strokeCurrent research projects:• Immediate changes of sing<strong>le</strong>-neuron activity in the contra<strong>le</strong>sional hemisphere following a primary motor cortex inactivation• Progressive reorganization of sing<strong>le</strong>-neuron activity in the contra<strong>le</strong>sional hemisphere following a primary motor cortex <strong>le</strong>sion• The reorganization of interhemispheric interactions and connections following a primary motor cortex <strong>le</strong>sionPublications choisies/Se<strong>le</strong>cted publicationsDancause N, Dykes RW, Miasnikov AA, Agueev V. Atropine-sensitive and -insensitive components of the somatosensory evoked potential. Brain Res. 2001 Aug10;910(1-2):67-73.Dancause N, Ptito A, Levin MF. Error correction strategies for motor behavior after unilateral brain damage: short-term motor <strong>le</strong>arning processes. Neuropsychologia.2002;40(8):1313-23.Dancause N, Barbay S, Frost SB, Plautz EJ, Chen D, Zoubina EV, Stowe AM, Nudo RJ. Extensive cortical rewiring after brain injury. J Neurosci. 2005 Nov2;25(44):10167-79.Dancause N, Barbay S, Frost SB, Plautz EJ, Popescu M, Dixon PM, Stowe AM, Friel KM, Nudo RJ. Topographically divergent and convergent connectivity betweenpremotor and primary motor cortex. Cereb Cortex. 2006 Aug;16(8):1057-68. Epub 2005 Oct 12.Dancause N, Barbay S, Frost SB, Plautz EJ, Stowe AM, Friel KM, Nudo RJ. Ipsilateral connections of the ventral premotor cortex in a new world primate. J Comp Neurol.2006 Apr 1;495(4):374-90.Dancause N, Barbay S, Frost SB, Zoubina EV, Plautz EJ, Mahnken JD, Nudo RJ. Effects of small ischemic <strong>le</strong>sions in the primary motor cortex on neurophysiologicalorganization in ventral premotor cortex. J Neurophysiol. 2006 Dec;96(6):3506-11. Epub 2006 Sep 20.Dancause N, Barbay S, Frost SB, Mahnken JD, Nudo RJ. Interhemispheric connections of the ventral premotor cortex in a new world primate. J Comp Neurol. 2007 Dec20;505(6):701-15.Dancause N, Duric V, Barbay S, Frost SB, Stylianous A, Nudo RJ. A new motor field in the lateral frontal cortex of squirrel monkeys. Cereb Cortex. 2008Dec;18(12):2719-28. Epub 2008 Apr 18.Page 33

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