01. Gene therapy Boulikas.pdf - Gene therapy & Molecular Biology

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Gene Ther Mol Biol Vol 1, 1-172. Ma
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I. Introduction Monumental progress
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The use of retroviral vectors in hu
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displaying the cleavable EGF domain
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molecules in the nucleus (Lowe and
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sensitive mutations which allow pro
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processed as described in panel A s
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On the contrary, the payload capaci
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in K562 human erythroleukemia cells
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defective HSV virus (DeLuca and Sch
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complex into the cytosol from the e
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Gene Therapy and Molecular Biology
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delivered by Sendai virus-liposome
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plasmids with the cell surface, tra
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infected by adenovirus alone; infec
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B. Transcription factor binding sit
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A closely related family of ubiquit
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cells. I-CreI is a member of this c
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C. Considerations of chromatin stru
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A. The molecular basis of cancer im
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fragments, or heat shock proteins c
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ecombinant vaccinia virus expressin
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HIV-1 envelope DNA construct develo
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inding sites A GYYY oriented in opp
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Prives, 1994). Whereas the wild-typ
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mutant p53 (mutations on p53 are wi
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master regulator of the cell cycle
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Work from several groups has shown
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chromatin condensation, drop in pH,
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Figure 23. A pathway leading to the
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Excessive necrotic death in cells o
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implantation, and similar processes
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normal cells in the surroundings. T
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A bicistronic retroviral vector (Ha
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C. Antisense ras gene transfer for
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equal to 6.0 showed S1 hyperreactiv
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protein (e.g. Smith et al, 1995; Fo
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transduced primary mouse fibroblast
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IL-1 - receptor antagonist protein
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p53 lung cancer retroviru s MHC cla
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designed by immunization with porti
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Isolation of an RNA aptamer that ca
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induction of human apoE in neonate
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atrium in heart, endothelial cells
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which eliminated tumors in small an
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C. Transfer of other genes against
Page 107 and 108: Gene Therapy and Molecular Biology
Page 109 and 110: significant reduction in neointima
Page 111 and 112: (Prehn et al, 1996); this implies a
Page 113 and 114: B. Approaches to gene therapy of RA
Page 115 and 116: of human immunoglobulin and antigen
Page 117 and 118: A. Etiology and mechanisms of destr
Page 121 and 122: However, CsA also inhibits the acti
Page 123 and 124: The peptide kinin, after binding to
Page 125 and 126: intake when administered to adrenal
Page 127 and 128: Introgen Therapeutics (Austin and H
Page 129 and 130: When a subfragment of only 513 bp o
Page 131 and 132: Armentano D, Zabner J, Sacks C, Soo
Page 133 and 134: Brady HJM, Miles CG, Pennington DJ,
Page 135 and 136: Chen J, Stickles RJ, Daichendt KA (
Page 137 and 138: Day ML, Wu S, Basler JW (1993) Pros
Page 139 and 140: Farmer G, Bargonetti J, Zhu H, Frie
Page 141 and 142: Giovannangeli C, Perrouault L, Escu
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Page 145 and 146: integrate in a site-specific fashio
Page 147 and 148: Li R, Waga S, Hannon GJ, Beach D, S
Page 149 and 150: adiation-induced apoptosis in the g
Page 151 and 152: Nakaya T, Iwai S, Fujinaga K, Sato
Page 153 and 154: Polyak K, Xia Y, Zweier JL, Kinzler
Page 155 and 156: macrophages from simian immunodefic
Page 157: intimal hyperplasia in a rat caroti
Page 161 and 162: Wattiaux R, Jadot M, Warnier-Pirott
Page 163 and 164: similar to mammalian interleukin-1
Page 167 and 168: 24. Gene Marking /Infectious Diseas
Page 169 and 170: Drug 50. Gene Therapy /Phase I /Can
Page 171 and 172: 76. Gene Therapy /Phase I /Cancer /
Page 173 and 174: 99. Gene Therapy /Phase II /Cancer
Page 175 and 176: 120. Gene Therapy /Phase I /Monogen
Page 179 and 180: cancer not specified) /Immunotherap
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