01. Gene therapy Boulikas.pdf - Gene therapy & Molecular Biology

Drug
50. Gene Therapy /Phase I
/Cancer /Colon
/Immunotherapy
51. Gene Therapy /Phase I
/Monogenic Disease
/Gaucher Disease
52. Gene Therapy /Phase I
/Infectious Disease
/Human
Immunodeficiency
Virus /Immunotherapy
53. Gene Therapy /Phase I
/Cancer /Melanoma
/Immunotherapy
54. Gene Therapy /Phase I
/Cancer /Neuroblastoma
/Immunotherapy
55. Gene Therapy /Phase I-
II /Infectious Disease
/Human
Immunodeficiency
Virus /Immunotherapy
56. Gene Therapy /Phase I
/Other /Rheumatoid
Arthritis
57. Gene Marking /Cancer
/Ovarian
58. Gene Marking /Cancer
/Pediatric Malignancies
59. Gene Therapy /Phase I
/Cancer /Breast
/Chemoprotection
60. Gene Therapy /Phase I
/Monogenic Disease
/Fanconi Anemia
61. Gene Therapy /Phase I
/Cancer /Glioblastoma
/Immunotherapy
62. Gene Therapy /Phase I
/Cancer /Melanoma
/Lymphoma /Breast
/Head and Neck Cancer
/Immunotherapy
Gene Therapy and Molecular Biology Vol 1, page 169
Injection of Colon Carcinoma Patients with
Autologous Irradiated Tumor Cells and Fibroblasts
Genetically Modified to Secrete Interleukin-2.
Retrovirus-Mediated Transfer of the cDNA for
Human Glucocerebrosidase into Peripheral Blood
Repopulating Cells of Patients with Gaucher's Disease.
An Open Label, Phase I /II Clinical Trial to
Evaluate the Safety and Biological Activity of HIV-
IT(V) (HIV-1 IIBenv /Retroviral Vector) in HIV-1
Infected Subjects.
Adoptive Immunotherapy of Cancer with Activated
Lymph Node Cells Primed In Vivo with Autologous
Tumor Cells Transduced with the GM-CSF Gene.
A Phase I Study of Immunization with γ Interferon
Transduced Neuroblastoma Cells.
A Phase I /II Pilot Study of the Safety of the
Adoptive Transfer of Syngeneic Gene-Modified
Cytotoxic T-Lymphocytes in HIV-Infected Identical
Twins.
Sponsor: NIH /Cell Genesys, Inc.
Clinical Trial to Assess the Safety, Feasibility, and
Efficacy of Transferring a Potentially Anti-arthritic
Cytokine Gene to Human Joints with Rheumatoid
Arthritis.
Use of a Retroviral Vector to Study the Trafficking
Patterns of Purified Ovarian TIL Populations Used in
Intraperitoneal Adoptive Immunotherapy of Ovarian
Cancer Patients: A Pilot Study.
Use of Double Marking with Retroviral Vectors to
Determine the Rate of Reconstitution of Untreated and
Cytokine Expanded CD34 + Selected Marrow Cells in
Patients Undergoing Autologous Bone Marrow
Transplantation.
Use of Safety-Modified Retroviruses to Introduce
Chemotherapy Resistance Sequences into Normal
Hematopoietic Cells for Chemoprotection During the
Therapy of Breast Cancer: A Pilot Trial.
Retroviral Mediated Gene Transfer of the Fanconi
Anemia Complementation Group C Gene to
Hematopoietic Progenitors of Group C Patients.
Injection of Glioblastoma Patients with Tumor Cells
Genetically Modified to Secrete Interleukin-2 (IL-2):
A Phase I Study.
IL-12 Gene Therapy Using Direct Injection of
Tumor with Genetically Engineered Autologous
Fibroblasts.
169
In Vitro /Autologous Fibroblasts /Lethally
Irradiated /In Combination with Untransduced
Autologous Tumor Cells /Retrovirus
/Interleukin-2 cDNA /Subcutaneous Injection
In Vitro /G-CSF Mobilized CD34 + Autologous
Peripheral Blood Cells /Retrovirus
/Glucocerebrosidase cDNA /Intravenous
In Vivo /Autologous Muscle Cells /Retrovirus
/HIV-1IIIB Envelope Protein /Intramuscular
Injection
In Vitro /Autologous Tumor Cells /Lethally
Irradiated /Used in Combination with Anti-CD3
and Interleukin-2 Primed Autologous Lymph
Node Cells to Prime Autologous Peripheral Blood
Cells In Vitro /Retrovirus /GM-CSF cDNA
/Intravenous
In Vitro /Autologous Tumor Cells /Allogeneic
Tumor Cells /Lethally Irradiated /Retrovirus /γ
Interferon cDNA /Subcutaneous Injection
In Vitro /CD8 + Syngeneic Peripheral Blood
Cells /Retrovirus /CD4-zeta Chimeric Receptor
/Intravenous /Concurrent Interleukin-2 Therapy
In Vivo /Autologous Synovial Cells /Retrovirus
/Interleukin-1 Receptor Antagonist Protein cDNA
/Intrajoint /Metacarpal Phalangeal Joints
In Vitro /Autologous Peripheral Blood Cells
/Autologous Tumor Infiltrating Lymphocytes
/Retrovirus /Neomycin Phosphotransferase cDNA
/Intraperitoneal
In Vitro /CD34+ Autologous Bone Marrow
Cells /Retrovirus /Neomycin Phosphotransferase
cDNA /Bone Marrow Transplant
In Vitro /CD34 + Autologous Peripheral Blood
Cells /Retrovirus /Multi-Drug Resistance-1
cDNA /Intravenous
In Vitro /CD34 + Autologous Peripheral Blood
Cells /Retrovirus /Fanconi Anemia
Complementation Group C cDNA /Intravenous
In Vitro /Autologous Fibroblasts /Lethally
Irradiated /In Combination with Untransduced
Autologous Tumor Cells /Lethally Irradiated
/Retrovirus /Cytokine /Interleukin-2 cDNA
/Subcutaneous Injection
In Vitro /Autologous Fibroblasts /Lethally
Irradiated /Retrovirus /Cytokine /Interleukin-12
cDNA /Neomycin Phosphotransferase cDNA
/Intratumoral /Direct Injection
Sobol, Robert E.
and Royston,
Ivor
Schuening,
Friedrich
Haubrich,
Richard and
Merritt, James A
Chang, Alfred E
Rosenblatt,
Joseph
Walker, Robert
Evans, C. H.
and Robbins,
Paul
Freedman,
Ralph
Heslop, Helen
Deisseroth,
Albert
Liu, Johnson,
M. and Young,
Neal S
Sobol, Robert
and Royston,
Ivor
Lotze, Michael
T