01. Gene therapy Boulikas.pdf - Gene therapy & Molecular Biology
01. Gene therapy Boulikas.pdf - Gene therapy & Molecular Biology
01. Gene therapy Boulikas.pdf - Gene therapy & Molecular Biology
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<strong>Gene</strong> Therapy and <strong>Molecular</strong> <strong>Biology</strong> Vol 1, page 165<br />
Appendix 1. RAC-approved human gene <strong>therapy</strong><br />
protocols<br />
Using retrovirus, protocols: 1-117<br />
Using adenovirus: 118-157<br />
With naked plasmid: 158-164<br />
Adeno-Associated virus: 165, 166<br />
Immuno<strong>therapy</strong> or other: 167-186<br />
Cationic lipids: 187-220 on page 203-206 of following article (Martin and <strong>Boulikas</strong>, 1998)<br />
(Last updated: 21 November 1997)<br />
RETROVIRAL GENE<br />
DELIVERY<br />
Disease Protocol title Procedures Principal<br />
investigator<br />
1. <strong>Gene</strong> Marking /Cancer The Treatment of Patients with Advanced Cancer<br />
Using Cyclophosphamide, Interleukin-2 and Tumor<br />
Infiltrating Lymphocytes.<br />
2. <strong>Gene</strong> Therapy /Phase I<br />
/Monogenic Disease<br />
/Severe Combined<br />
Immune Deficiency due<br />
to Adenosine<br />
Deaminase Deficiency<br />
3. <strong>Gene</strong> Therapy /Phase I<br />
/Cancer /Melanoma<br />
/Immuno<strong>therapy</strong><br />
4. <strong>Gene</strong> Marking /Cancer<br />
/Acute Myelogenous<br />
Leukemia<br />
5. <strong>Gene</strong> Marking /Cancer<br />
/Neuroblastoma<br />
6. <strong>Gene</strong> Marking /Cancer<br />
/Neuroblastoma<br />
7. <strong>Gene</strong> Marking /Cancer<br />
/Chronic Myelogenous<br />
Leukemia<br />
8. <strong>Gene</strong> Marking /Acute<br />
Hepatic Failure<br />
9. <strong>Gene</strong> Marking /Cancer<br />
/Melanoma<br />
10. <strong>Gene</strong> Therapy /Phase I<br />
/Cancer /Melanoma<br />
Treatment of Severe Combined Immune Deficiency<br />
(SCID) due to Adenosine Deaminase (ADA)<br />
Deficiency with Autologous Lymphocytes Transduced<br />
with the Human ADA <strong>Gene</strong>: An Experimental Study.<br />
<strong>Gene</strong> Therapy of Patients with Advanced Cancer<br />
Using Tumor Infiltrating Lymphocytes Transduced<br />
with the <strong>Gene</strong> Coding for Tumor Necrosis Factor.<br />
Autologous Bone Marrow Transplant for Children<br />
with Acute Myelogenous Leukemia in First Complete<br />
Remission: Use of Marker <strong>Gene</strong>s to Investigate the<br />
<strong>Biology</strong> of Marrow Reconstitution and the Mechanism<br />
of Relapse.<br />
A Phase I /II Trial of High Dose Carboplatin and<br />
Etoposide with Autologous Marrow Support for<br />
Treatment of Stage D Neuroblastoma in First<br />
Remission: Use of Marker <strong>Gene</strong>s to Investigate the<br />
<strong>Biology</strong> of Marrow Reconstitution and the Mechanism<br />
of Relapse.<br />
A Phase II Trial of High-Dose Carboplatin and<br />
Etoposide with Autologous Marrow Support for<br />
Treatment of Relapse /Refractory Neuroblastoma<br />
Without Apparent Bone Marrow Involvement.<br />
Autologous Bone Marrow Transplantation for<br />
Chronic Myelogenous Leukemia in which Retroviral<br />
Markers are Used to Discriminate between Relapse<br />
which Arises from Systemic Disease Remaining after<br />
PreparativeTherapy Versus Relapse due to Residual<br />
Leukemic Cells in Autologous Marrow: A Pilot Trial.<br />
Hepatocellular Transplantation in Acute Hepatic<br />
Failure and Targeting <strong>Gene</strong>tic Markers to Hepatic<br />
Cells.<br />
The Administration of Interleukin-2 and Tumor<br />
Infiltrating Lymphocytes to Patients with Melanoma.<br />
Immunization of Cancer Patients Using Autologous<br />
Cancer Cells Modified by Insertion of the <strong>Gene</strong> for<br />
165<br />
In Vitro /Tumor Infiltrating Lymphocytes<br />
/Retrovirus /Neomycin Phosphotransferase cDNA<br />
/Intravenous<br />
In Vitro /Autologous Peripheral Blood Cells<br />
/CD34 + Autologous Peripheral Blood Cells /Cord<br />
Blood /Placenta Cells /Retrovirus /Adenosine<br />
Deaminase cDNA /Neomycin Phosphotransferase<br />
cDNA /Intravenous<br />
In Vitro /Tumor Infiltrating Lymphocytes<br />
/Retrovirus /Cytokine /Tumor Necrosis Factor<br />
cDNA /Neomycin Phosphotransferase cDNA<br />
/Intravenous<br />
In Vitro /Autologous Bone Marrow Cells<br />
/Retrovirus /Neomycin Phosphotransferase cDNA<br />
/Bone Marrow Transplant<br />
In Vitro /Autologous Bone Marrow Cells<br />
/Retrovirus /Neomycin Phosphotransferase cDNA<br />
/Bone Marrow Transplant<br />
In Vitro /Autologous Bone Marrow Cells<br />
/Retrovirus /Neomycin Phosphotransferase cDNA<br />
/Bone Marrow Transplant<br />
In Vitro /Autologous Bone Marrow Cells<br />
/Retrovirus /Neomycin Phosphotransferase cDNA<br />
/Bone Marrow Transplant<br />
In Vitro /Autologous Hepatocytes /Retrovirus<br />
/Neomycin Phosphotransferase cDNA<br />
/Intrahepatic<br />
In Vitro /Tumor Infiltrating Lymphocytes<br />
/Retrovirus /Neomycin Phosphotransferase cDNA<br />
/Intravenous<br />
In Vitro /Autologous Tumor Cells /Lethally<br />
Irradiated /Retrovirus /Cytokine /Tumor Necrosis<br />
Rosenberg,<br />
Steven A<br />
Blaese, R.<br />
Michael<br />
Rosenberg,<br />
Steven A<br />
Brenner,<br />
Malcolm K.<br />
Brenner,<br />
Malcolm K.<br />
Brenner,<br />
Malcolm K<br />
Deisseroth,<br />
Albert B<br />
Ledley, Fred D.<br />
Lotze, Michael<br />
T<br />
Rosenberg,<br />
Steven A
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