01. Gene therapy Boulikas.pdf - Gene therapy & Molecular Biology

More documents

Recommendations

Info

184. Gene Therapy /Phase I / Cancer /Ovarian /Immunotherapy 185. Gene Therapy /Phase I /Cancer /Colorectal /Immunotherapy (under review) 186. Gene Therapy /Phase I /Cancer /CEA- Expressing Malignancies /Immunotherapy (under review) Boulikas: An overview on gene therapy Human Interleukin-12 (ALVAC-hIL-12) in Patients with Surgically Incurable Melanoma Sponsor: National Cancer Institute-Cancer Therapy Evaluation Program (NCI-CTEP) Intraperitoneal (IP) Auatologous Therapeutic Tumor Vaccine (AUT-OV-ALVAC-hB7.1) plus IP rIFN-γ for Patients with Ovarian Cancer. A Pilot Study Sponsor: NCI Cancer Therapy Evaluation Program (NCI-CTEP) Phase I Clinical Trial of a Recombinant ALVAC- CEA-B7 Vaccine in the Treatment of Advanced Colorectal Carcinoma. Sponsor: National Cancer Institute-Cancer Therapy Evaluation Program (NCI-CTEP) Phase I /Pilot Study of ALVAC-CEA-B7.1 Immunization in Patients with Advanced Adenocarcinoma Expressing CEA Sponsor: National Cancer Institue - Cancer Therapy Evaluation Program (NCI-CTEP) 180 In Vitro /Autologous Tumor Cells /Canarypox Virus /B7.1 (CD80) /Intraperitoneal Injection In Vivo /Autologous Tumor Cells /Canarypox Virus /Carcinoembryonic Antigen /B7.1 (CD80) /Intradermal Scarification In Vivo /Autologous Tumor Cells /Canarypox Virus /Carcinoembryonic Antigen /B7.1 (CD80) /Intramuscular and Intradermal Injections Freedman, Ralph Kaufman, Howard L von Mehren, Margaret
Page 1 and 2:
Gene Ther Mol Biol Vol 1, 1-172. Ma
Page 3 and 4:
I. Introduction Monumental progress
Page 5 and 6:
The use of retroviral vectors in hu
Page 7 and 8:
displaying the cleavable EGF domain
Page 9 and 10:
molecules in the nucleus (Lowe and
Page 11 and 12:
sensitive mutations which allow pro
Page 13 and 14:
processed as described in panel A s
Page 15 and 16:
On the contrary, the payload capaci
Page 17 and 18:
in K562 human erythroleukemia cells
Page 19 and 20:
defective HSV virus (DeLuca and Sch
Page 21 and 22:
complex into the cytosol from the e
Page 23 and 24:
Gene Therapy and Molecular Biology
Page 25 and 26:
delivered by Sendai virus-liposome
Page 27 and 28:
plasmids with the cell surface, tra
Page 29 and 30:
infected by adenovirus alone; infec
Page 31 and 32:
Page 33 and 34:
B. Transcription factor binding sit
Page 35 and 36:
A closely related family of ubiquit
Page 37 and 38:
cells. I-CreI is a member of this c
Page 39 and 40:
Page 41 and 42:
C. Considerations of chromatin stru
Page 43 and 44:
Page 45 and 46:
A. The molecular basis of cancer im
Page 47 and 48:
fragments, or heat shock proteins c
Page 49 and 50:
ecombinant vaccinia virus expressin
Page 51 and 52:
HIV-1 envelope DNA construct develo
Page 53 and 54:
inding sites A GYYY oriented in opp
Page 55 and 56:
Page 57 and 58:
Prives, 1994). Whereas the wild-typ
Page 59 and 60:
mutant p53 (mutations on p53 are wi
Page 61 and 62:
master regulator of the cell cycle
Page 63 and 64:
Work from several groups has shown
Page 65 and 66:
chromatin condensation, drop in pH,
Page 67 and 68:
Figure 23. A pathway leading to the
Page 69 and 70:
Excessive necrotic death in cells o
Page 71 and 72:
implantation, and similar processes
Page 73 and 74:
normal cells in the surroundings. T
Page 75 and 76:
Page 77 and 78:
Page 79 and 80:
A bicistronic retroviral vector (Ha
Page 81 and 82:
C. Antisense ras gene transfer for
Page 83 and 84:
equal to 6.0 showed S1 hyperreactiv
Page 85 and 86:
protein (e.g. Smith et al, 1995; Fo
Page 87 and 88:
transduced primary mouse fibroblast
Page 89 and 90:
IL-1 - receptor antagonist protein
Page 91 and 92:
p53 lung cancer retroviru s MHC cla
Page 93 and 94:
Page 95 and 96:
designed by immunization with porti
Page 97 and 98:
Isolation of an RNA aptamer that ca
Page 99 and 100:
induction of human apoE in neonate
Page 101 and 102:
atrium in heart, endothelial cells
Page 103 and 104:
which eliminated tumors in small an
Page 105 and 106:
C. Transfer of other genes against
Page 107 and 108:
Page 109 and 110:
significant reduction in neointima
Page 111 and 112:
(Prehn et al, 1996); this implies a
Page 113 and 114:
B. Approaches to gene therapy of RA
Page 115 and 116:
of human immunoglobulin and antigen
Page 117 and 118:
A. Etiology and mechanisms of destr
Page 119 and 120:
Page 121 and 122:
However, CsA also inhibits the acti
Page 123 and 124:
The peptide kinin, after binding to
Page 125 and 126:
intake when administered to adrenal
Page 127 and 128:
Introgen Therapeutics (Austin and H
Page 129 and 130: When a subfragment of only 513 bp o
Page 131 and 132: Armentano D, Zabner J, Sacks C, Soo
Page 133 and 134: Brady HJM, Miles CG, Pennington DJ,
Page 135 and 136: Chen J, Stickles RJ, Daichendt KA (
Page 137 and 138: Day ML, Wu S, Basler JW (1993) Pros
Page 139 and 140: Farmer G, Bargonetti J, Zhu H, Frie
Page 141 and 142: Giovannangeli C, Perrouault L, Escu
Page 143 and 144: the neoplastic phenotype by replace
Page 145 and 146: integrate in a site-specific fashio
Page 147 and 148: Li R, Waga S, Hannon GJ, Beach D, S
Page 149 and 150: adiation-induced apoptosis in the g
Page 151 and 152: Nakaya T, Iwai S, Fujinaga K, Sato
Page 153 and 154: Polyak K, Xia Y, Zweier JL, Kinzler
Page 155 and 156: macrophages from simian immunodefic
Page 157 and 158: intimal hyperplasia in a rat caroti
Page 159 and 160: Trono D, Feinberg MB, Baltimore D (
Page 161 and 162: Wattiaux R, Jadot M, Warnier-Pirott
Page 163 and 164: similar to mammalian interleukin-1
Page 165 and 166: Gene Therapy and Molecular Biology
Page 167 and 168: 24. Gene Marking /Infectious Diseas
Page 169 and 170: Drug 50. Gene Therapy /Phase I /Can
Page 171 and 172: 76. Gene Therapy /Phase I /Cancer /
Page 173 and 174: 99. Gene Therapy /Phase II /Cancer
Page 175 and 176: 120. Gene Therapy /Phase I /Monogen
Page 177 and 178: Gene Therapy and Molecular Biology
Page 179: cancer not specified) /Immunotherap
show all

01. Gene therapy Boulikas.pdf - Gene therapy & Molecular Biology

Create successful ePaper yourself

Delete template?

Save as template?