01. Gene therapy Boulikas.pdf - Gene therapy & Molecular Biology
01. Gene therapy Boulikas.pdf - Gene therapy & Molecular Biology
01. Gene therapy Boulikas.pdf - Gene therapy & Molecular Biology
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
120. <strong>Gene</strong> Therapy /Phase I<br />
/Monogenic Disease<br />
/Cystic Fibrosis<br />
121. <strong>Gene</strong> Therapy /Phase I<br />
/Monogenic Disease<br />
/Cystic Fibrosis<br />
122. <strong>Gene</strong> Therapy /Phase I<br />
/Monogenic Disease<br />
/Cystic Fibrosis<br />
123. <strong>Gene</strong> Therapy /Phase I<br />
/Monogenic Disease<br />
/Cystic Fibrosis<br />
124. <strong>Gene</strong> Therapy /Phase I<br />
/Cancer /Non-small Cell<br />
Lung Cancer /Tumor<br />
Suppressor <strong>Gene</strong><br />
125. <strong>Gene</strong> Therapy /Phase I<br />
/Monogenic Disease<br />
/Cystic Fibrosis<br />
126. <strong>Gene</strong> Therapy /Phase I<br />
/Cancer /Central<br />
Nervous System /Pro-<br />
Drug<br />
127. <strong>Gene</strong> Therapy /Phase I<br />
/Cancer /n /Pro-Drug<br />
128. <strong>Gene</strong> Therapy /Phase I<br />
/Monogenic Disease<br />
/Cystic Fibrosis<br />
129. <strong>Gene</strong> Therapy /Phase I<br />
/Monogenic Disease<br />
/Cystic Fibrosis<br />
130. <strong>Gene</strong> Therapy /Phase I<br />
/Cancer /Head and Neck<br />
Squamous Cell /Tumor<br />
Suppressor <strong>Gene</strong><br />
131. <strong>Gene</strong> Therapy /Phase I<br />
/Cancer /Colon /Hepatic<br />
Metastases /Tumor<br />
Suppressor <strong>Gene</strong><br />
132. <strong>Gene</strong> Therapy /Phase I<br />
/Cancer /Central<br />
Nervous System<br />
Malignancies /Pro-<br />
Drug<br />
<strong>Gene</strong> Therapy and <strong>Molecular</strong> <strong>Biology</strong> Vol 1, page 175<br />
Cystic Fibrosis <strong>Gene</strong> Therapy Using an Adenovirus<br />
Vector: In Vivo Safety and Efficacy in Nasal<br />
Epithelium.<br />
Sponsor: Genzyme Corporation<br />
A Phase I Study of <strong>Gene</strong> Therapy of Cystic Fibrosis<br />
Utilizing a Replication Deficient Recombinant<br />
Adenovirus Vector to Deliver the Human Cystic<br />
Fibrosis Transmembrane Conductance Regulator<br />
cDNA to the Airways.<br />
Sponsor: <strong>Gene</strong>tic Therapy, Inc. /Novartis<br />
<strong>Gene</strong> Therapy for Cystic Fibrosis Using E1 Deleted<br />
Adenovirus: A Phase I Trial in the Nasal Cavity.<br />
Adenovirus-Mediated <strong>Gene</strong> Transfer of CFTR to the<br />
Nasal Epithelium and Maxillary Sinus of Patients with<br />
Cystic Fibrosis.<br />
Sponsor: Genzyme Corporation<br />
Clinical Protocol for Modification of Tumor<br />
Suppressor <strong>Gene</strong> Expression and Induction of<br />
Apoptosis in Non-Small Cell Lung Cancer (NSCLC)<br />
with an Adenovirus Vector Expressing Wildtype p53<br />
and Cisplatin.<br />
Evaluation of Repeat Administration of a<br />
Replication Deficient, Recombinant Adenovirus<br />
Containing the Normal Cystic Fibrosis<br />
Transmembrane Conductance Regulator cDNA to the<br />
Airways of Individuals with Cystic Fibrosis.<br />
Treatment of Advanced CNS Malignancy with the<br />
Recombinant Adenovirus H5.020RSVTK: A Phase I<br />
Trial.<br />
Treatment of Advanced Mesothelioma with the<br />
Recombinant Adenovirus H5.010RSVTK: A Phase I<br />
Trial.<br />
Adenovirus Mediated <strong>Gene</strong> Transfer for Cystic<br />
Fibrosis: Safety of Single Administration in the Lung<br />
(lobar instillation).<br />
Sponsor: Genzyme Corporation<br />
Adenovirus Mediated <strong>Gene</strong> Transfer for Cystic<br />
Fibrosis: Safety of a Single Administration in the<br />
Lung (aerosol administration).<br />
Sponsor: Genzyme Corporation<br />
Clinical Protocol for Modification of Tumor<br />
Suppressor <strong>Gene</strong> Expression in Head and Neck<br />
Squamous Cell Carcinoma (HNSCC) with an<br />
Adenovirus Vector Expressing Wild-type p53.<br />
<strong>Gene</strong> Therapy of Primary and Metastatic Malignant<br />
Tumors of the Liver Using ACN53 Via Hepatic Artery<br />
Infusion: A Phase I Study.<br />
Sponsor: Schering Plough Corporation (formerly<br />
Canji)<br />
Phase I Study of Adenoviral Vector Delivery of the<br />
HSV-TK <strong>Gene</strong> and the Intravenous Administration of<br />
Ganciclovir in Adults with Malignant Tumors of the<br />
Central Nervous System.<br />
175<br />
In Vivo /Nasal Epithelial Cells /Adenovirus<br />
/Serotype 2 /Cystic Fibrosis Transmembrane<br />
Conductance Regulator cDNA /Intranasal<br />
In Vivo /Nasal Epithelial Cells /Respiratory<br />
Epithelial Cells /Adenovirus /Serotype 5 /Cystic<br />
Fibrosis Transmembrane Conductance Regulator<br />
cDNA /Intranasal /Respiratory Tract<br />
Administration (Bronchoscope)<br />
In Vivo /Nasal Epithelial Cells /Adenovirus<br />
/Serotype 5 /Cystic Fibrosis Transmembrane<br />
Conductance Regulator CDNA /Intranasal<br />
In Vivo /Nasal Epithelial Cells /Maxillary Sinus<br />
Epithelial Cells /Adenovirus /Serotype 2 /Cystic<br />
Fibrosis Transmembrane Conductance Regulator<br />
cDNA /Intranasal /Maxillary Sinus<br />
Administration<br />
In Vivo /Autologous Tumor Cells /Adenovirus<br />
/Serotype 5 /p53 cDNA /Intratumoral<br />
/Bronchoscope<br />
In Vivo /Nasal Epithelial Cells /Respiratory<br />
Epithelial Cells /Adenovirus /Serotype 5 /Cystic<br />
Fibrosis Transmembrane Conductance Regulator<br />
cDNA /Intranasal /Respiratory Tract<br />
Administration (Bronchoscope) /Multiple Dose<br />
In Vivo /Autologous Tumor Cells /Adenovirus<br />
/Serotype 5 /Herpes Simplex Virus Thymidine<br />
Kinase cDNA /Ganciclovir /Stereotactic Injection<br />
In Vivo /Autologous Tumor Cells /Adenovirus<br />
/Serotype 5 /Herpes Simplex Virus Thymidine<br />
Kinase cDNA /Ganciclovir /Intrapleural<br />
In Vivo /Respiratory Epithelial Cells<br />
/Adenovirus /Serotype 2 /Cystic Fibrosis<br />
Transmembrane Conductance Regulator cDNA<br />
/Respiratory Epithelial Cells /Bronchoscope<br />
In Vivo /Respiratory Epithelial Cells<br />
/Adenovirus /Serotype 2 /Cystic Fibrosis<br />
Transmembrane Conductance Regulator cDNA<br />
/Respiratory Epithelial Cells /Aerosol<br />
Administration<br />
In Vivo /Autologous Tumor Cells /Adenovirus<br />
/Serotype 5 /p53 cDNA /Intratumoral<br />
/Bronchoscope<br />
In Vivo /Autologous Tumor Cells /Adenovirus<br />
/Serotype 5 /p53 cDNA /Intrahepatic /Hepatic<br />
Artery /Bolus Infusion<br />
In Vivo /Autologous Tumor Cells /Adenovirus<br />
/Serotype 5 /Herpes Simplex Virus Thymidine<br />
Kinase cDNA /Ganciclovir /Intra- tumoral<br />
/Stereotactic Injection<br />
Welsh, Michael<br />
J and Smith,<br />
Alan E<br />
Wilmott, Robert<br />
W<br />
Boucher,<br />
Richard C. and<br />
Knowles,<br />
Michael R<br />
Welsh, Michael<br />
J<br />
Roth, Jack A<br />
Crystal, Ronald<br />
G<br />
Eck, Stephen L.<br />
and Alavi, Jane<br />
B<br />
Albelda, Steven<br />
M<br />
Dorkin, Henry L<br />
and Lapey,<br />
Allen<br />
Dorkin, Henry<br />
L. and Lapey,<br />
Allen<br />
Clayman, Gary<br />
Venook, Alan<br />
and Warren,<br />
Robert<br />
Grossman,<br />
Robert and<br />
Woo, Savio