01. Gene therapy Boulikas.pdf - Gene therapy & Molecular Biology

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63. Gene Therapy /Phase I /Cancer /Prostate /Immunotherapy 64. Gene Therapy /Phase I /Cancer /Breast /Antisense 65. Gene Therapy /Phase I /Monogenic Disease /Hunter Syndrome 66. Gene Marking /Cancer /Lymphoma /Breast 67. Gene Therapy /Phase I /Cancer /Melanoma /Immunotherapy 68. Gene Therapy /Phase I /Cancer /Astrocytoma /Pro-Drug 69. Gene Therapy /Phase I /Cancer /Ovarian / Pro- Drug 70. Gene Therapy /Phase I /Cancer /Melanoma /Immunotherapy 71. Gene Therapy /Phase I /Cancer /Melanoma /Immunotherapy 72. Gene Therapy /Phase I /Monogenic Disease /Chronic Granulomatous Disease 73. Gene Therapy /Phase II /Infectious Disease /Human Immunodeficiency Virus /Immunotherapy 74. Gene Marking /Cancer /Chronic Myelogenous Leukemia 75. Gene Therapy /Phase I /Cancer /Multiple Myeloma /Pro-Drug Boulikas: An overview on gene therapy Phase I /II Study of Autologous Human GM-CSF Gene Transduced Prostate Cancer Vaccines in Patients with Metastatic Prostate Carcinoma. Gene Therapy for the Treatment of Metastatic Breast Cancer by In Vivo Infection with Breast- Targeted Retroviral Vectors Expressing Antisense cfos or Antisense c-myc RNA. Retroviral-Mediated Transfer of the Iduronate-2- Sulfatase Gene into Lymphocytes for Treatment of Mild Hunter Syndrome (Mucopolysaccharidosis Type II). High Dose Chemotherapy and Autologous Bone Marrow plus Peripheral Blood Stem Cell Transplantation for Patients with Lymphoma or Metastatic Breast Cancer: Use of Marker Genes to Investigate the Biology of Hematopoietic Reconstitution in Adults. A Phase I Study of Vaccination with Autologous, Irradiated Melanoma Cells Engineered to Secrete Human Granulocyte-Macrophage Colony Stimulating Factor. Stereotaxic Injection of Herpes Simplex Thymidine Kinase Vector Producer Cells (PA317 /G1TkSvNa.7) and Intravenous Ganciclovir for the Treatment of Recurrent Malignant Glioma. Sponsor: Genetic Therapy, Inc. /Novartis A Phase I Trial of In Vivo Gene Therapy with Herpes Simplex Thymidine Kinase /Ganciclovir System for the Treatment of Refractory or Recurrent Ovarian Cancer. A Phase I Testing of Genetically Engineered Interleukin-7 Melanoma Vaccines. Phase I /II Study of Immunization with MHC Class I Matched Allogeneic Human Prostatic Carcinoma Cells Engineered to Secrete Interleukin-2 and Interferon-γ Gene Therapy Approach for Chronic Granulomatous Disease. A Repeat Dose Safety and Efficacy Study of HIV- IT(V) in HIV-1 Infected Subjects with Greater Than or Equal to 100 CD4 + T Cells and No AIDS Defining Symptoms. Autologous Marrow Transplantation for Chronic Myelogenous Leukemia Using Stem Cells Obtained After In Vivo Chemotherapy Cytokine Priming. Thymidine Kinase (TK) Transduced Donor Leukocyte Infusions as a Treatment for Patients with Relapsed or Persistent Multiple Myeloma after T-cell Depleted Allogeneic Bone Marrow Transplant. Sponsor: Genetic Therapy, Inc. /Novartis 170 In Vitro /Autologous Tumor Cells /Lethally Irradiated /Retrovirus /Cytokine /Granulocyte- Macrophage Colony Stimulating Factor cDNA /Subcutaneous Injection In Vivo /Autologous Tumor Cells /Retrovirus /c-fos Antisense RNA /c-myc Antisense /Intrapleural /Intraperitoneal In Vitro /Autologous Peripheral Blood Cells /Retrovirus /Iduronate-2-Sulfatase cDNA /Intravenous In Vitro /CD34 + Autologous Bone Marrow Cells /CD34 + Autologous Peripheral Blood Cells /Retrovirus /Neomycin Phosphotransferase cDNA /Bone Marrow Transplant In Vitro /Autologous Tumor Cells /Lethally Irradiated /Retrovirus /Cytokine /Granulocyte- Macrophage Colony Stimulating FactorcDNA /Subcutaneous Injection In Vivo /Autologous Tumor Cells /PA317 /Retrovirus /Herpes Simplex Virus Thymidine Kinase cDNA /Ganciclovir /Intratumoral /Stereotactic Injection In Vivo /Autologous Tumor Cells /PA317 /Retrovirus /Herpes Simplex Virus Thymidine Kinase cDNA /Ganciclovir /Intraperitoneal /Catheter In Vitro /Allogeneic Tumor Cells /Lethally Irradiated /Retrovirus /Cytokine /Interleukin-7 cDNA /Hygromycin Phosphotransferase /Herpes Simplex Virus Thymidine Kinase cDNA /Subcutaneous Injection In Vitro /HLA-Matched Allogeneic Tumor Cells /Lethally Irradiated /Retrovirus /Cytokine /Interleukin-2 cDNA /γ Interferon cDNA /Subcutaneous Injection In Vitro /G-CSF Mobilized CD34 + Autologous Peripheral Blood Cells /Retrovirus /p47phox /Intravenous In Vivo /Autologous Muscle Cells /Retrovirus /HIV-1IIIB Envelope Protein /Intramuscular Injection In Vitro /Autologous G-CSF and ATA-C Mobilized Bone Marrow Cells /Retrovirus /Neomycin Phosphotransferase cDNA /Bone Marrow Transplant In Vitro /Allogeneic T Lymphocytes /Retrovirus /Herpes Simplex Thymidine Kinase /Ganciclovir /Intravenous Simons, Jonathan Holt, Jeffrey, and Arteaga, Carlos B Whitley, Chester B Douer, Dan and Kenneth Norris Dranoff, Glen Fetell, Michael Link, Charles and Moorman, Donald Economou, James Gansbacher, Bernd Malech, Harry Parenti, David Verfaillie, Catherine Munshi, Nikhil C. and Barlogie, Bart
76. Gene Therapy /Phase I /Cancer /Ovarian /Immunotherapy 77. Gene Therapy /Phase I /Monogenic Disease /Purine Nucleoside Phosphorylase Deficiency 78. Gene Therapy /Phase I /Infectious Disease /Human Immunodeficiency Virus / Replication Inhibition /Single Chain Antibody Gene 79. Human Immunodeficiency Virus-1 /Immunotherapy 80. Gene Therapy /Phase I /Cancer /Glioma /Immunotherapy 81. Gene Therapy /Phase I /Human Immunodeficiency Virus-1 82. Gene Therapy /Phase I /Cancer /Prostate /Antisense 83. Gene Marking /Cancer /EBV-Positive Hodgkin Disease 84. Gene Marking /Cancer /EBV-Positive Hodgkin Disease 85. Gene Therapy /Phase II /Infectious Disease /Human Immunodeficiency Virus 86. Gene Therapy /Phase I /Infectious Disease /Human Immunodeficiency Virus /Replication Inhibition 87. Gene Therapy /Phase I /Cancer /Metastatic Melanoma /Immunotherapy 88. Gene Therapy /Phase I /Infectious Disease Gene Therapy and Molecular Biology Vol 1, page 171 Treatment of Patients with Advanced Epithelial Ovarian Cancer using Anti-CD3 Stimulated Peripheral Blood Lymphocytes Transduced with a Gene Encoding a Chimeric T-cell Receptor Reactive with Folate Binding Protein. Gene Therapy for Purine Nucleoside Phosphorylase Deficiency. Intracellular Antibodies Against HIV-1 Envelope Protein for AIDS Gene Therapy. A Randomized, Double Blinded, Phase I /II Dosing Study to Evaluate the Safety and Optimal CTL Inducing Dose of HIV-IT(V) in Pre-Selected HIV-1 Infected Subjects. Gene Therapy of Malignant Gliomas: A Phase I Study of IL-4 Gene -Modified Autologous Tumor to Elicit an Immune Response. Phase I Study to Evaluate the Safety of Cellular Adoptive Immunotherapy using Autologous Unmodified and Genetically Modified CD8 + HIV- Specific T Cells in HIV Seropositive Individuals. Sponsor: Targeted Genetics Corporation Gene Therapy for the Treatment of Advanced Prostate Cancer by In Vivo Transduction with Prostate-Targeted Retroviral Vectors Expressing Antisense c-myc RNA. Administration of Neomycin Resistance Gene Marked EBV Specific Cytotoxic T Lymphocytes as Therapy for Patients Receiving a Bone Marrow Transplant for Relapsed EBV-Positive Hodgkin Disease. Administration of Neomycin Resistance Gene Marked EBV Specific Cytotoxic T Lymphocytes to Patients with Relapsed EBV-Positive Hodgkin Disease. A Randomized, Controlled, Phase II Study of the Activity and Safety of Autologous CD4-Zeta Gene- Modified T Cells in HIV-Infected Patients. Sponsor: Cell Genesys Phase I Study to Evaluate the Safety and In Vivo Persistence of Adoptively Transferred Autologous CD4 + T Cells Genetically Modified to Resist HIV Replication. Phase I Study to Evaluate the Safety of Cellular Adoptive Immunotherapy Using Autologous Unmodified and Genetically Modified CD8 + Tyrosinase-Specific T Cells in Patients with Metastatic Melanoma. Intracellular Immunization Against HIV-1 Infection Using an Anti-Rev Single Chain Variable Fragment 171 In Vitro /Anti-CD3 Stimulated Autologous Peripheral Blood Lymphocytes /Retrovirus /Antibody /MOv-γ (Reactive with Folate Binding Protein) /Intravenous /Intraperitoneal In Vitro /Autologous Peripheral Blood Lymphocytes /Retrovirus /Purine Nucleoside Phosphorylase cDNA /Intravenous In Vitro /CD4 + Autologous Peripheral Blood Lymphocytes /Retrovirus /sFv105 Anti-HIV-1 Envelope Protein(gp160)Gene /Intravenous In Vivo /Autologous Muscle Cells /Retrovirus /HIV-1IIIB Envelope Protein /Intramuscular Injection In Vitro /Autologous Tumor (Glioma) Cells /Non-Irradiated /Retrovirus /Cytokine /Interleukin-4 cDNA /Subcutaneous Injection In Vitro /CD8 + Allogeneic Cytotoxic T Lymphocytes /CD8 + Syngeneic Cytotoxic T Lymphocytes /Retrovirus /Neomycin Phosphotransferase /Herpes Simplex Virus Thymidine Kinase cDNA /Retrovirus /Intravenous In Vivo /Autologous Tumor Cells /Retrovirus /Antisense c-myc RNA /Intraprostate Injection In Vitro /EBV-Specific Cytotoxic T Lymphocytes /Retrovirus /Neomycin Phosphotransferase cDNA /Bone Marrow Transplant In Vitro /EBV-Specific Cytotoxic T Lymphocytes /Retrovirus /Neomycin Phosphotranspherase cDNA /Intravenous Administration In Vitro /Autologous CD8 + T Cells /Retrovirus /CD4-Zeta Chimeric Receptor /Intravenous In Vitro /Autologous CD4 + T Cells /Retrovirus /Neomycin Phosphotransferase Gene /PolyTAR Decoy Gene /RRE-polyTAR Decoy Gene In Vitro /Autologous CD8 + Tyrosinase-Specific TCells /Retrovirus /Hygromycin Phosphotranspherase /Intravenous Administration In Vitro /Autologous CD4 + Peripheral Blood Lymphocytes /Retrovirus /Anti-Rev SFv Hwu, Patrick McIvor, R. Scott Marasco, Wayne A Conant, Marcus Bozik, Michael Riddell, Stanley R Steiner, Mitchell S Roskrow, Marie Roskrow, Marie Connick, Elizabeth Greenberg, Philip D Yee, Cassian and Greenberg, Philip D Pomerantz, Roger J
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Gene Ther Mol Biol Vol 1, 1-172. Ma
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I. Introduction Monumental progress
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The use of retroviral vectors in hu
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displaying the cleavable EGF domain
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molecules in the nucleus (Lowe and
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sensitive mutations which allow pro
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processed as described in panel A s
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On the contrary, the payload capaci
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in K562 human erythroleukemia cells
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defective HSV virus (DeLuca and Sch
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complex into the cytosol from the e
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Gene Therapy and Molecular Biology
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delivered by Sendai virus-liposome
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plasmids with the cell surface, tra
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infected by adenovirus alone; infec
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B. Transcription factor binding sit
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A closely related family of ubiquit
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cells. I-CreI is a member of this c
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C. Considerations of chromatin stru
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A. The molecular basis of cancer im
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fragments, or heat shock proteins c
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ecombinant vaccinia virus expressin
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HIV-1 envelope DNA construct develo
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inding sites A GYYY oriented in opp
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Prives, 1994). Whereas the wild-typ
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mutant p53 (mutations on p53 are wi
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master regulator of the cell cycle
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Work from several groups has shown
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chromatin condensation, drop in pH,
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Figure 23. A pathway leading to the
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Excessive necrotic death in cells o
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implantation, and similar processes
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normal cells in the surroundings. T
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A bicistronic retroviral vector (Ha
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C. Antisense ras gene transfer for
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equal to 6.0 showed S1 hyperreactiv
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protein (e.g. Smith et al, 1995; Fo
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transduced primary mouse fibroblast
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IL-1 - receptor antagonist protein
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p53 lung cancer retroviru s MHC cla
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designed by immunization with porti
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Isolation of an RNA aptamer that ca
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induction of human apoE in neonate
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atrium in heart, endothelial cells
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which eliminated tumors in small an
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C. Transfer of other genes against
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significant reduction in neointima
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(Prehn et al, 1996); this implies a
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B. Approaches to gene therapy of RA
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of human immunoglobulin and antigen
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A. Etiology and mechanisms of destr
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Page 121 and 122: However, CsA also inhibits the acti
Page 123 and 124: The peptide kinin, after binding to
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Page 127 and 128: Introgen Therapeutics (Austin and H
Page 129 and 130: When a subfragment of only 513 bp o
Page 131 and 132: Armentano D, Zabner J, Sacks C, Soo
Page 133 and 134: Brady HJM, Miles CG, Pennington DJ,
Page 135 and 136: Chen J, Stickles RJ, Daichendt KA (
Page 137 and 138: Day ML, Wu S, Basler JW (1993) Pros
Page 139 and 140: Farmer G, Bargonetti J, Zhu H, Frie
Page 141 and 142: Giovannangeli C, Perrouault L, Escu
Page 143 and 144: the neoplastic phenotype by replace
Page 145 and 146: integrate in a site-specific fashio
Page 147 and 148: Li R, Waga S, Hannon GJ, Beach D, S
Page 149 and 150: adiation-induced apoptosis in the g
Page 151 and 152: Nakaya T, Iwai S, Fujinaga K, Sato
Page 153 and 154: Polyak K, Xia Y, Zweier JL, Kinzler
Page 155 and 156: macrophages from simian immunodefic
Page 157 and 158: intimal hyperplasia in a rat caroti
Page 159 and 160: Trono D, Feinberg MB, Baltimore D (
Page 161 and 162: Wattiaux R, Jadot M, Warnier-Pirott
Page 163 and 164: similar to mammalian interleukin-1
Page 167 and 168: 24. Gene Marking /Infectious Diseas
Page 169: Drug 50. Gene Therapy /Phase I /Can
Page 173 and 174: 99. Gene Therapy /Phase II /Cancer
Page 175 and 176: 120. Gene Therapy /Phase I /Monogen
Page 179 and 180: cancer not specified) /Immunotherap
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