3. Umbruch 4.4..2005 - Online Pot

Role of the endocannabinoid system in learning and memory 113
Table 1. Effects of cannabinoid agonists in behavioral learning and memory paradigms
(a) Rats
Model Drug Observations Reference
Operant: ∆ 9 -THC Delay-dependent disruptions of performance [18]
delayed match (correlated with decreased hippocampal
and delayed activity)
non-match to Tolerance developed to ∆ 9 -THC-induced [21]
sample non- disruptions with repeated testing
match to place
∆ 9 -THC, anand- ∆ 9 -THC and R-methanandamide disrupted [24]
amide, R-me- performance, blocked by SR-141716
thanandamide
WIN-55,212-2 Delay-dependent disruptions [19]
Tolerance developed to daily dosing of
3.75 mg/kg
[170]
∆ 9 -THC, Decrease in performance associated with [20]
WIN-55,212-2 impaired hippocampal firing, blocked by
SR-141716
∆ 9 -THC, Both produced working-memory deficits [22]
anandamide
(+PMSF)
Both produced working-memory deficits,
reversed by SR-141716
[23]
Operant: repeated ∆ 9 -THC Tolerance to performance deficits [25]
acquisition Deficits sensitive to estrogen [26]
Radial arm maze ∆ 9 -THC Disruptions after acute and chronic dosing [32]
Increased errors [37]
∆ 9 -THC-induced disruption blocked by
SR-141716
[61]
Microinjections in hippocampus, not
other regions, produce deficits
[33, 90]
Impaired retention, decreased activity [171]
CP-55,940 Impaired performance, blocked by [36]
SR-141716 and epstastigmine
∆ 9 -THC, ∆ 9 -THC, WIN-55,212, and CP-55940 [33]
WIN-55,212, impaired performance
CP-55940,
anandamide
Water maze HU-210 Impaired acquisition [38]
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∆ 9 -THC Deficits in working memory [172]
Nabilone, ∆ 8 -THC ∆ 8 -THC, not nabilone, disrupted place learning [173]
∆ 9 -THC, WIN-55,212 disrupts learning, ∆ 9 -THC [174]
WIN-55,212 produces place-aversion