3. Umbruch 4.4..2005 - Online Pot

114 S.A. Varvel and A.H. Lichtman
Table 1. (Continued)
(a) Rats
Model Drug Observations Reference
T-maze ∆ 9 -THC Working-memory deficits [41]
Working-memory deficits, inhibition of
acetylcholine release. Blocked by SR-141716,
sulpiride
[175]
No tolerance after twice-daily injections for
14 days
[43]
Object recognition ∆ 9 -THC Disrupted at 10 mg/kg, lower doses [176]
potentiated by ethanol
(b) Mice
CP-55,940, Decreased learning/performance [177]
methanandamide
Model Drug Observations Reference
Water maze ∆ 9 -THC Working-memory deficits, reversed by
SR-141716
[39]
Working-memory deficits reversed by
bicuculline
[42]
Deficits in acquisition and working memory,
reversed by SR-141716
[178]
∆ 9 -THC, Working-memory deficits not present in [40]
WIN-55,212, CB 1-knockout mice
methanandamide
Passive avoidance Anandamide Post-training anandamide (short, not long,
interval) impaired retention, blocked by D1 and D2 agonists
[44]
Intra-hippocampal anandamide, post training,
disrupted retention
[45]
Post-training anandamide impaired retention
in DBA/2 mice, improved it in C57BL/6 mice;
both effects blocked by naltrexone
[48]
Anandamide disrupted consolidation, effect
modulated by stress, blocked by naltrexone
[46]
Interaction between subthreshold doses of
of anandamide + morphine on consolidation
[47]
(Continued on next page)
solidation, encoding, and retrieval processes. Thus, the endocannabinoid system
may play selective roles in different components of memory, as well as in
different types of memory.