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3. Umbruch 4.4..2005 - Online Pot

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Cannabinoid chemistry: an overview 35<br />

Structure 13<br />

Recently the discovery of a further class of diarylpyrazolines with high<br />

potency and selectivity for the CB 1 receptor was described [103]. These compounds<br />

were found to be CB 1 antagonists. SLV319 was found to be a potent<br />

CB 1 antagonist (K i = 7.8 nM) close to that of the Sanofi compound<br />

SR-141716A, with more than 1000-fold selectivity against CB 2.<br />

Structure 14<br />

Additional synthetic compounds that bind to the CB 1 and/or CB 2 receptors<br />

have been mentioned in patents. These were recently reviewed by Hertzog<br />

[104].

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