3. Umbruch 4.4..2005 - Online Pot

The development of Sativex ® – a natural cannabis-based medicine 245
Figure 3. Administration of Sativex ® .
ters’ of symptoms in individual patients as reported in GW’s clinical programme,
demonstrates the real strength and potential of Sativex ® as a medicine.
These beneficial effects are not only due to the pharmacological actions
of the medicine but also due to the flexibility of dosing that the medicine
offers. It accommodates inter-individual variation, but also allows each patient
to establish a dose regimen that provides patient benefits with minimal
unwanted side effects. It allows patients the opportunity to develop their own
dosing regimen, including dosing interval and acceptable dose range, and also
enables them to assess the time course of symptom relief, using their own personal
endpoints as markers of efficacy and tolerability. In this way, the patient
is able to optimize the relief of their symptoms, while minimising and resolving
the occurrence of any side effects that they may experience (i.e. patiens can
target the therapeutic window).
By utilizing this approach, a number of significant clinical benefits of
Sativex ® have been reported in GW’s clinical trial programme.
Clinical effects of Sativex ®
The clinical effects of Sativex ® have undergone investigation in an international
clinical trials programme, with centres in UK, Romania, Belgium,