3. Umbruch 4.4..2005 - Online Pot

Cannabinoids: effects on vomiting and nausea in animal models 187
Table 1, there is considerable evidence that cannabinoids attenuate vomiting in
emetic species. Cannabinoids have been shown to reduce vomiting in cats [30],
pigeons [65, 66], ferrets [33–35], least shrews, Cryptotis parva [24–29] and
the house musk shrew, Suncus murinus [31, 32].
Table 1. Effect of cannabinoid on emesis across species
Species Emetogen Cannabinoid Effect on
emesis
Cat Cisplatin (7.5 mg/kg, iv) Nabilone (0.025–0.1 mg/kg, iv) ↓ [30]
N-Methyllevonantradol
(0.003–0.02 mg/kg, iv)
↓ [30]
Dog Cisplatin (3 mg/kg, iv) Nabilone (0.1 mg/kg, iv) – [67]
Apomorphine ∆ 9- (0.05–5 mg/kg, iv)
THC (0.003–0.3 mg/kg, iv) – [68]
Pigeon Cisplatin (10 mg/kg, iv) ∆ 9 -THC (5.0 mg/kg) with CuCl2 HU-211 (2.5 mg/kg) with CuCl2 ↓ [65]
↓ [65]
Cisplatin (7.5 mg/kg, iv) HU-210 (0.012–0.05 mg/kg, sc) ↓ [66]
Emetine (20 mg/kg, sc) HU-210 (0.012–0.05 mg/kg, sc) ↓ [66]
Ferret Morphine (1 mg/kg, sc) WIN55,212–2 (0.03–0.13 mg/kg, sc) ↓ [33]
Morphine-6-glucuronide ∆ 9 -THC (1 mg/kg, ip) ↓ [34]
(M6G; 0.05 mg/kg, sc) WIN-55,212-2 (1 mg/kg, ip) ↓ [34]
Methanandamide (3 mg/kg, ip) ↓ [34]
Cisplatin (10 mg/kg iv) ∆ 9 -THC (0.1–1.0 mg/kg ip) ↓ [35]
C. parva SR-141716A (20 mg/kg, ip) CP-55,940 (1 mg/kg, ip) ↓ [24]
(least WIN-55,212–2 (10 mg/kg, ip) ↓ [26]
shrew) ∆ 9 -THC (20 mg/kg, ip) ↓ [24]
Cisplatin (20 mg/kg, ip) ∆ 9 -THC (1–10 mg/kg, ip) ↓ [25]
WIN-55,212-2 (1–5 mg/kg, ip) ↓ [25]
CP-55,940 (0.025–0.3 mg/kg) ↓ [29]
2-AG (2.5–10 mg/kg, ip) CP-55,940 (0.05–0.1 mg/kg, ip) ↓ [27]
WIN-55,212–2 (1–5 mg/kg, ip) ↓ [27]
∆ 9 -THC (2.5–5 mg/kg, ip) ↓ [27]
CBD (10–20 mg/kg, ip) – [27]
Anandamide (5 mg/kg, ip) ↓ [27]
Methanandamide (10 mg/kg, ip) ↓ [27]
SR-141716A (2.5–5 mg/kg, ip) ↓ [27]
5-HTP (100 mg/kg, ip) ∆ 9 -THC (5–20 mg/kg, ip) ↓ [28]
5-HT (5 mg/kg, ip) ∆ 9 -THC (20 mg/kg, ip) ↓ [28]
2-methylserotonin (5-HT3 ∆ 9 agonist; 5 mg/kg, ip)
-THC (20 mg/kg, ip)
∆
↓ [28]
9 -THC (20 mg/kg, ip) ↓ [28]
S. murinus Cisplatin (20 mg/kg, ip) ∆ 9 -THC (2.5–10 mg/kg, ip) ↓ [32]
(house CBD (5–10 mg/kg, ip) ↓ [32]
musk shrew) LiCl2 (390 mg/kg, ip) ∆ 9 -THC (3–20 mg/kg, ip) ↓ [31]
CBD (5–10 mg/kg, ip) ↓ [31]
?, reduced; –, no effect; iv, intravenous; sc, subcutaneous; ip, intraperitoneal.