3. Umbruch 4.4..2005 - Online Pot

Cannabinoid targets for pain therapeutics 159
characterization of a cannabinoid receptor in rat brain. Mol Pharmacol 34: 605–613
6 Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990) Structure of a cannabinoid
receptor and functional expression of the cloned cDNA. Nature 346: 561–564
7 Munro S, Thomas KL, Abu-Shaar M (1993) Molecular characterization of a peripheral receptor
for cannabinoids. Nature 365: 61–65
8 Devane WA, Hanusˇ L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum
A, Etinger A, Mechoulam R (1992) Isolation and structure of a brain constituent that binds to the
cannabinoid receptor. Science 258: 1946–1949
9 Pertwee RG (1997) Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol Ther 74:
129–180
10 Palmer SL, Thakur GA, Makriyannis A (2002) Cannabinergic ligands. Chem Phys Lipids 121:
3–19
11 Walker JM, Krey JF, Chu CJ, Huang SM (2002) Endocannabinoids and related fatty acid derivatives
in pain modulation. Chem Phys Lipids 121: 159–172
12 Dixon WE (1899) The pharmacology of Cannabis indica. Br Med J 2: 1354–1357
13 Bicher HI, Mechoulam R (1968) Pharmacological effects of two active constituents of marihuana.
Arch Int Pharmacodyn Ther 172: 24–31
14 Kosersky DS, Dewey WL, Harris LS (1973) Antipyretic, analgesic and anti-inflammatory effects
of delta 9-tetrahydrocannabinol in the rat. Eur J Pharmacol 24: 1–7
15 Bloom AS, Dewey WL, Harris LS, Brosius KK (1977) 9-nor-9beta-hydroxyhexahydrocannabinol,
a cannabinoid with potent antinociceptive activity: comparisons with morphine. J Pharmacol Exp
Ther 200: 263–270
16 Buxbaum DM (1972) Analgesic activity of 9-tetrahydrocannabinol in the rat and mouse.
Psychopharmacologia 25: 275–280
17 Martin BR, Compton DR, Thomas BF, Prescott WR, Little PJ, Razdan RK, Johnson MR, Melvin
LS, Mechoulam R, Ward SJ (1991) Behavioral, biochemical, and molecular modeling evaluations
of cannabinoid analogs. Pharmacol Biochem Behav 40: 471–478
18 Hohmann AG, Martin WJ, Tsou K, Walker JM (1995) Inhibition of noxious stimulus-evoked
activity of spinal cord dorsal horn neurons by the cannabinoid WIN 55,212-2. Life Sci 56:
2111–2118
19 Hohmann AG, Tsou K, Walker JM (1998) Cannabinoid modulation of wide dynamic range neurons
in the lumbar dorsal horn of the rat by spinally administered WIN55,212-2. Neurosci Lett
257: 119–122
20 Hohmann AG, Tsou K, Walker JM (1999) Cannabinoid suppression of noxious heat-evoked activity
in wide dynamic range neurons in the lumbar dorsal horn of the rat. J Neurophys 81: 575–583
21 Martin WJ, Hohmann AG, Walker JM (1996) Suppression of noxious stimulus-evoked activity in
the ventral posterolateral nucleus of the thalamus by a cannabinoid agonist: correlation between
electrophysiological and antinociceptive effects. J Neurosci 16: 6601–6611
22 Strangman NM, Walker JM (1999) The cannabinoid WIN 55,212-2 inhibits the activity-dependent
facilitation of spinal nociceptive responses. J Neurophys 81: 472–477
23 Drew LJ, Harris J, Millns PJ, Kendall DA, Chapman V (2000) Activation of spinal cannabinoid 1
receptors inhibits C-fibre driven hyperexcitable neuronal responses and increases
[ 35 S]GTPgammaS binding in the dorsal horn of the spinal cord of noninflamed and inflamed rats.
Eur J Neurosci 12: 2079–2086
24 Kelly S, Chapman V (2001) Selective cannabinoid CB1 receptor activation inhibits spinal nociceptive
transmission in vivo. J Neurophysiol 86: 3061–3064
25 Hunt SP, Pini A, Evan G (1987) Induction of c-fos-like protein in spinal cord neurons following
sensory stimulation. Nature 328: 632–634
26 Farquhar-Smith WP, Jaggar SI, Rice AS (2002) Attenuation of nerve growth factor-induced visceral
hyperalgesia via cannabinoid CB(1) and CB(2)-like receptors. Pain 97: 11–21
27 Hohmann AG, Tsou K, Walker JM (1999) Intrathecal cannabinoid administration suppresses noxious-stimulus
evoked Fos protein-like immunoreactivity in rat spinal cord: comparison with morphine.
Acta Pharmacologica Sinica 20: 1132–1136
28 Martin WJ, Loo CM, Basbaum AI (1999) Spinal cannabinoids are anti-allodynic in rats with persistent
inflammation. Pain 82: 199–205
29 Nackley AG, Makriyannis A, Hohmann AG (2003) Selective activation of cannabinoid CB2 receptors
suppresses spinal Fos protein expression and pain behavior in a rat model of inflammation.
Neuroscience 119: 747–757