3. Umbruch 4.4..2005 - Online Pot

178 L. De Petrocellis et al.
factor receptor down-regulation and ceramide production. Prostate 56: 1–12
37 Portella G, Laezza C, Laccetti P, De Petrocellis L, Di Marzo V, Bifulco M (2003) Inhibitory effects
of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on
signals involved in angiogenesis and metastasis. FASEB J 17: 1771–1773
38 Sanchez C, de Ceballos ML, del Pulgar TG, Rueda D, Corbacho C, Velasco G, Galve-Roperh I,
Huffman JW, Ramon y Cajal S, Guzman M (2001) Inhibition of glioma growth in vivo by selective
activation of the CB(2) cannabinoid receptor. Cancer Res 61: 5784–5789
39 McKallip RJ, Lombard C, Fisher M, Martin BR, Ryu S, Grant S, Nagarkatti PS, Nagarkatti M
(2002) Targeting CB 2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic
disease. Blood 100: 627–634
40 Sanchez C, Galve-Roperh I, Canova C, Brachet P, Guzman M (1998) Delta9-tetrahydrocannabinol
induces apoptosis in C6 glioma cells. FEBS Lett 436: 6–10
41 Ruiz L., Miguel A, Diaz-Laviada I (1999) Delta9-tetrahydrocannabinol induces apoptosis in
human prostate PC-3 cells via a receptor-independent mechanism. FEBS Lett 458: 400–404
42 Galve-Roperh I, Sanchez C, Cortes ML, del Pulgar TG, Izquierdo M, Guzman M (2000)
Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular
signal-regulated kinase activation. Nat Med 6: 313–319
43 Gomez del Pulgar T, Velasco G, Sanchez C, Haro A, Guzman M (2002) De novo-synthesized
ceramide is involved in cannabinoid-induced apoptosis. Biochem J 363: 183–188
44 Ramer R, Weinzierl U, Schwind B, Brune K, Hinz B (2003) Ceramide is involved in
r(+)-methanandamide-induced cyclooxygenase-2 expression in human neuroglioma cells. Mol
Pharmacol 64: 1189–1198
45 Guzman M (2003) Cannabinoids: potential anticancer agents. Nat Rev Cancer 3: 745–755
46 Sarker KP, Obara S, Nakata M, Kitajima I, Maruyama I (2000) Anandamide induces apoptosis of
PC-12 cells: involvement of superoxide and caspase-3. FEBS Lett 472: 39–44
47 Sarker KP, Biswas KK, Rosales JL, Yamaji K, Hashiguchi T, Lee KY, Maruyama I (2003) Ebselen
inhibits NO-induced apoptosis of differentiated PC12 cells via inhibition of ASK1-p38
MAPK-p53 and JNK signaling and activation of p44/42 MAPK and Bcl-2. J Neurochem 87:
1345–1353
48 Rak J, Mitsuhashi Y, Sheehan C, Tamir A, Viloria-Petit A, Filmus J, Mansour SJ, Ahn NG, Kerbel
RS (2000) Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth
factor up-regulation in ras-transformed epithelial cells and fibroblasts. Cancer Res 60: 490–498
49 Hetian L, Ping A, Shumei S, Xiaoying L, Luowen H, Jian W, Lin M, Meisheng L, Junshan Y,
Chengchao S (2002) A novel peptide isolated from a phage display library inhibits tumor growth
and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain
receptor. J Biol Chem 277: 43137–43142
50 Casanova ML, Larcher F, Casanova B, Murillas R, Fernandez-Acenero MJ, Villanueva C,
Martinez-Palacio J, Ullrich A, Conti CJ, Jorcano JL (2002) A critical role for ras-mediated, epidermal
growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis. Cancer Res
62: 3402–3407
51 Blazquez C, Casanova ML, Planas A, Del Pulgar TG, Villanueva C, Fernandez-Acenero MJ,
Aragones J, Huffman JW, Jorcano JL, Guzman M (2003) Inhibition of tumor angiogenesis by
cannabinoids. FASEB J 17: 529–531
52 Joseph J, Niggemann B, Zaenker KS, Entschladen F (2004) Anandamide is an endogenous
inhibitor for the migration of tumor cells and T lymphocytes. Cancer Immunol Immunother 53:
723–728
53 Pagotto U, Marsicano G, Fezza F, Theodoropoulou M, Grubler Y, Stalla J, Arzberger T, Milone A,
Losa M, Di Marzo V et al. (2001) Normal human pituitary gland and pituitary adenomas express
cannabinoid receptor type 1 and synthesize endogenous cannabinoids: first evidence for a direct
role of cannabinoids on hormone modulation at the human pituitary level. J Clin Endocrinol
Metab 86: 2687–2696
54 Maccarrone M, Attina M, Cartoni A, Bari M, Finazzi-Agrò (2001) A Gas chromatography-mass
spectrometry analysis of endogenous cannabinoids in healthy and tumoral human brain and
human cells in culture. J Neurochem 76: 594–601
55 Schmid PC, Wold LE, Krebsbach RJ, Berdyshev EV, Schmid HH (2002) Anandamide and other
N-acylethanolamines in human tumors. Lipids 37: 907–912
56 Maccarrone M (2004) Levels of N-acylethanolamines in human tumors: in search of reliable data.
Lipids 39: 193–194