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Self Instructional Manual for Cancer Registrars - SEER - National ...

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Bilirubin. Bilirubin is a pigment excreted normally by the gallbladder and liver. An<br />

elevated bilirubin is indicative of obstruction of the gallbladder or of hepatic disease which<br />

affects the function of the liver. Normal values are: One rain. 0.4 mg/100 ml. Direct: 0.4<br />

mg/100 ml. Total: 0.7 mg/100 ml. Indirect is total minus direct.<br />

BUN (Blood urea nitrogen). An elevated BUN may result in uremia reflecting the<br />

failure of the kidneys to excrete normal waste materials. For example, it occurs frequently<br />

in patients with cancer of the cervix and bladder where extensive growth of the cancer<br />

obstructs the ureters. Normal values are 8-25 mg/100 mi.<br />

Ul_c Acid. In any malignancy with rapid destruction of cells, uric acid may be elevated.<br />

It is of particular interest in patients with lymphoma, Hodgkin's disease, lymphosarcoma,<br />

polycythemia vera, and leukemia treated by radiation therapy and/or chemotherapy. Normal<br />

values are 3.0-7.0 mg/ml.<br />

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