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Self Instructional Manual for Cancer Registrars - SEER - National ...

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EXAMPLE<br />

G8<br />

DEPARTMENT<br />

OF PATHOLOGY<br />

Date: 8/9/91 Location Service<br />

Reg. No. 000044 Name Ralph C. Sark Age 65 Race White Sex Male<br />

Occupation Student Dept. of Pathology Accession No. $91-7896<br />

Surgeon M. Sterling. MD Nature of Operation Bone marrow biopsy<br />

HISTORY OF CASE: Malignant lymphoma<br />

SPECIMEN:<br />

Bone marrow<br />

GROSS DESCRIPTION: Received in a test tube and representing products of bone<br />

marrow biopsy<br />

ASPIRATE<br />

SECTION:<br />

Markedly hypercellular megakaryocytes<br />

Decreased stainable iron is normal<br />

Malignant Lymphoma (See comment)<br />

SMEAR:<br />

90% abnormal cells<br />

04% erythroid<br />

02% granulocytie<br />

04% small lymphocytes<br />

See comment<br />

DIAGNOSIS:<br />

Previously diagnosed<br />

90% abnormal cells<br />

COMMENT:<br />

malignant lymphoma<br />

The bone marrow is almost totally replaced by atypical lymphoid cells, with the<br />

development of a leukemic phase. Approximately 90% of cells in the peripheral blood are<br />

abnormal. The abnormal cell is a large cell with a high nuclear cytoplasm ratio, pale blue<br />

vacuolated cytoplasm, reticular nuclear chromatin with 1-2 nucleoli. Special stains reveal<br />

markedly positive PAS stain. Sudan black stain and peroxidase stain are negative.<br />

Michael Cosm, MD<br />

Pathologist<br />

221

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