ICAS-PAT manual for Design of process monitoring and ... - CAPEC

Equipments Operations Main stream in Side stream in Main stream out Side stream out
Mixing tank Mixing Mixed media Water Mixed media
Media
Heat sterilizer Heat sterilization Sterilized media
Fermentor Fermentation Ammonia Biomass Air
Air
Figure 8: Input/output information to draw the flowsheet (fermentation process)
Water
Mixing tank
Heat sterilizer
Ammonia
Fermentor
Air
Media
Air
Mixing
Heat sterilization
Fermentation
Biomass
Figure 9: Generated flowsheet (fermentation process)
3.3. Process analysis (Step 3)
The following steps need to be taken in this phase of the design procedure (see Figure
10):
3.3.1. Click on the command button, “List the process points”.
3.3.2. Write the path of the directory containing the knowledge base (e.g.
D:/PAT/knowledge base.xls) in the provided list box (the browse option can be
used to search the file and copy the directory of file) and click on the command
button, “List the variables related to each process point”.
3.3.3. Process variables are user specific. Thus, the user has to check each listed process
variable thoroughly, and modify the list if needed (remove the unnecessary
variables from the list, or add extra variables if required. Note that no empty
(blank) cells should be left between the variables).
3.3.4. Write the values of the lower and the upper operational limit, and add the unit of
each listed variable in the place reserved for that information. The user can refer to
a data sheet (data_sheet.xls) to access this information.
After completing Step 3, click on the command button “4. Sensitivity analysis” to
proceed to the next step of the design procedure.
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