ICAS-PAT manual for Design of process monitoring and ... - CAPEC

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Appendix A: report generated in MS Word Design of process monitoring and analysis system (PAT system) Step1: Product quality specifications 1. Specifications of Biomass Value Unit Composition 2.95 % (w/w) Concentration 30.00 g/l 2. Specifications of Glucose Value Unit Composition 4.00 % (w/w) Concentration 40.69 g/l 3. Specifications of Salts Value Unit Composition 0.58 % (w/w) Concentration 5.93 g/l 4. Specifications of Water Value Unit Composition 92.46 % (w/w) Concentration 939.44 g/l Step2: Process specifications Equipment list Fermentor Sterilizer Mixing tank Raw material list Starter culture Glucose Salts Water Ammonia Air Step3: Process analysis Process points Process variables Lower limit Upper limit Unit Fermentor DO (Dissolved oxygen) 0.00067 0.007 Kg/m3 Dissolved CO2 0.0005 0.004 Kg/m3 pH 6 7 Temperature 293 310 K Pressure 1 2 atm Inlet flow rate of air 0 10 m/s Outlet flow rate of air 0 10 m/s Inlet flow rate of NH3 0 10 m/s Outlet flow rate of NH3 0 10 m/s Substrate concentration 1 180 Kg/m3 Biomass concentration 1 30 Kg/m3 29
Cell mass 30 900 kg Foaming level 0 0.01 m Stirrer speed 0 10 rps Cell growth rate 0.1 0.15 hr-1 Homogeneity 0.7 1 fractional homogeneous Sterilizer Steam temperature 120 200 oC Main stream temperature 120 150 oC Main stream flow rate 300 700 Kg/hr Steam flow rate 0 1000 Kg/hr Sterilization duration 0 7 hour Mixing tank Stirrer speed 0 36000 rps Step4: Sensitivity analysis Mixing time 0 3 hour Homogeneity 0.95 1 Fractional homogeneous Critical process points Mixing tank Sterilizer Fermentor Fermentor Fermentor Fermentor Fermentor Critical process variables Homogeneity Main stream temperature DO (Dissolved oxygen) pH Dissolved CO2 Temperature Homogeneity Step5: Interdependency analysis Critical process points Critical process variables Actuators Mixing tank Homogeneity Mixing time Sterilizer Main stream temperature Steam flow rate Fermentor DO (Dissolved oxygen) Air flow rate Fermentor pH Flow rate of NH3 Fermentor Dissolved CO2 Air flow rate Fermentor Temperature Coolant flow rate Fermentor Homogeneity Stirrer speed Step6: Performance analysis of monitoring tools Critical points Critical variables Monitoring Monitoring tools techniques Mixing tank Homogeneity NIR EPP 2000 Fiber Optic Spectrometer- NIR2 Sterilizer Main stream temperature Thermistor DO-35 Interchangeable Thermistor -- 103JL1A Fermentor DO (Dissolved oxygen) Optical sensor FOXY Sensor System 30
Page 1 and 2: ICAS-PAT manual for Design of proce
Page 3 and 4: 1. Introduction 1.1. Prerequisites
Page 5 and 6: Figure 2: Find applications of moni
Page 7 and 8: Figure 3: Knowledge/data retrieval
Page 9 and 10: Figure 4: Problem specific interfac
Page 11 and 12: 3.1. Product quality specifications
Page 13 and 14: Equipments Operations Main stream i
Page 15 and 16: • Click on the command button, fi
Page 17 and 18: Figure 12: MoT model interface 3.5.
Page 19 and 20: Data management (interdependency an
Page 21 and 22: 3.6.3. Grading of monitoring tools:
Page 23 and 24: 3.7. Proposed process monitoring an
Page 25 and 26: and pH are within the limits and co
Page 27 and 28: Figure 19: Sensitivity verification
Page 29: Feed Mixing tank Mixing time Homoge

ICAS-PAT manual for Design of process monitoring and ... - CAPEC

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