92 RECENT ADVANCES ON GLUTEN TOXICITY cell epitope in naïve and sensitized mice. J Exp Med 1993; 178: 1783-8. 9. Hoyne GF, Jamicki AG, Thomas WR, Lamb JR. Characterization <strong>of</strong> the specificity and duration <strong>of</strong> T cell tolerance to intranasally administered peptides in mice: a role for intramolecular epitope suppression. Int Immunol 1997; 9: 1165-73. 10. Steinman L. Despite epitope spreading in the pathogenesis <strong>of</strong> autoimmune <strong>disease</strong>, highly restricted approaches to immune therapy may still succeed (with a edge on this bet). J Autoimmun 2000; 14: 278-82. 11. Wu B, Wu J-M, Miagkov A, Adams RN, Levitsky HI, Drachman DB. Specific immunotherapy by genetically engineered APCs: the "guided missile" strategy. J Immunol 2001; 166: 4773-9. 12. Wang W, Uzzau S, Goldblum SE, et al. Human zonulin, a potential modulator <strong>of</strong> intestinal tight junctions. J Cell Sci 2000; 113: 24, 4435-44. 13. Fasano A, Not T, Wang W, et al. Zonulin, a newly discovered modulator <strong>of</strong> intestinal permeability, and its expression in <strong>coeliac</strong> <strong>disease</strong>. Lancet 2000; 355:1518-1519. 14. Clemente MG, De Virgiliis S, Kang JS, Macatagney R, Congia M, Fasano A. New insights on celiac <strong>disease</strong> pathogenesis: gliadin-induced zonulin release, actin polymerization, and early increased gut permeability. Gut (in press). 15. Drago S, DiPierro M, Giambelluca D, Iacono G, Catassi C, Fasano A. Gliadin induces occludin down-regulation and tight junctions (tj) disassembly in human intestine. 10th International Symposium on Coeliac Disease Paris (France), June 2-5, 2002.
Index A Antiendomysium antibodies (EMA), 33-37 Antigen presenting cells, 3, 17-18, 67 specific T cells, 18, 90 -specific therapies, 17 B Barley, 1, 23-24, 27, 31, 43, 53, 75, 83 B cell, 17-18, 62 Breast feeding, 46-48 C Cytokines, 6, 17-19, 68 IL-10, 68, 85-86 interferon gamma (IFNγ), 6, 18, 21, 48, 68, 86 TGF-β1, 48 Th1 associated, 19 Th1-like, 17 tumour necrosis factor (TNF), 6, 18 D Deamidation, 4-5, 14, 19, 90 Dendritic cells, 17, 67-68 Detoxified grains, 78-79, 89 E Environmental factors gut infections, 3 Infant feeding, 45, 52, 54, 56 role <strong>of</strong>, 36-37, 43 Epidemic <strong>of</strong> <strong>coeliac</strong> <strong>disease</strong>, 44-45, 52, 54 Epitope, 4-7, 14, 22, 24, 84, 90 dominant, 90 hierarchies, 20-21, 90 toxic, 28 Extracellular matrix degeneration, 6 F Familial clustering, 31-32, 35, 43 G Genetic predisposition, 36, 61 CTLA4, 2, 83-84 DQ2, 2-4, 6-7, 13, 17, 28, 32, 37, 44, 61, 83, 85 DQ7, 2-3 DQ8, 2-4, 6-7, 13, 28, 32, 44, 61, 83, 85 DR3, 2-3, 35-37 DR4, 2-3 DR5, 2-3 DR7, 2-3 5qter, 2 11qter, 2 Gliadin, 1, 4, 75-77, 91 A-gliadin, 19-23, 25, 27-28, 89 31-49, 28 57-73 QE65, 22-24, 90 57-68, 90 57-89, 90 62-75, 90 deamidation <strong>of</strong>, 19 epitopes, 84, 90 HLA-DQ2 restricted, 22, 24 fractions, 27-28 toxicity, 28 genes, 90 intranasal administration, 86 peptides, 28, 91 Gluten, 1, 3-4, 6, 17, 43-44, 48, 51, 54, 61, 64, 67, 75 age at introduction <strong>of</strong>, 49 amount <strong>of</strong>, 47-49, 54, 56 challenge, 18, 21, 25 -containing cereals consumption <strong>of</strong>, 48 genetic modification <strong>of</strong>, 56 intake, 52 consumption <strong>of</strong>, 48 deamidation, 4 -derived peptides, 3 epitopes, 4-7, 14 free diet, 7, 17-18, 21, 61, 83 immune tolerance <strong>of</strong>, 64 in follow-on formula, 48 in the Saharawi's diet, 37 intolerance, 65 native, 90 peptides, 4, 37, 85, 89 deamidation, 5, 13-14 dominant, 90 immune tolerance to, 56 "toxic", 19 33-mer, 90 proteins, 4 high-molecular weight, 76 medium-molecular weight, 76 93
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Perspectives on Coeliac Disease Vol
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The AIC Meeting was held in the Aul
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Italian Coeliac Society, Via Picott
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Preface Coeliac disease (CD) is a u
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Contents Current understanding of t
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2 THE BASIS OF COELIAC DISEASE hapl
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4 THE BASIS OF COELIAC DISEASE 1 pr
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6 THE BASIS OF COELIAC DISEASE spre
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8 THE BASIS OF COELIAC DISEASE Ackn
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10 THE BASIS OF COELIAC DISEASE glu
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Catassi C, Fasano A, Corazza GR (ed
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T CELL RESPONSES TO GLUTEN PEPTIDES
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18 A DOMINANT EPITOPE IN GLUTEN PEP
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20 A DOMINANT EPITOPE IN GLUTEN PEP
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22 A DOMINANT EPITOPE IN GLUTEN PEP
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24 A DOMINANT EPITOPE IN GLUTEN PEP
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26 A DOMINANT EPITOPE IN GLUTEN PEP
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28 ROLE OF A-GLIADIN 31-49 PEPTIDE
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Catassi C, Fasano A, Corazza GR (ed
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COELIAC DISEASE IN THE SAHARAWI 33
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COELIAC DISEASE IN THE SAHARAWI 35
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COELIAC DISEASE IN THE SAHARAWI 37
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COELIAC DISEASE IN THE SAHARAWI 39
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