primary prevention of coeliac disease - Associazione Italiana ...

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xii risk factors that can trigger the onset of CD, particularly infant feeding, is discussed in detail. Finally, new strategies of treatment, based on either the introduction of genetically detoxified grains or induction of oral tolerance to gluten, are presented. The reader will appreciate that the “holy grail” for a possible coeliac cure is still far away. Biochemically speaking, the complexity of gluten toxicity is disarming. Furthermore, the lack of an animal model of disease greatly hampers the investigations on the CD pathophysiology at the mucosal level. In spite of these problems, the route has been traced and primary prevention of CD should not be considered an utopia anymore at the beginning of the third millennium. We hope that this volume will stimulate researchers and clinicians alike to pursue this goal. We express our gratitude to all speakers and chairmen at the Pavia meeting, and to the academic authorities of the University of Pavia. We gratefully acknowledge the support of the AIC National Board, particularly of Ing. Spinelli, who was one of the promoters of this meeting that unfortunately passed away. The publication of this volume would not have been possible without the expertise of the AIC Editorial Board, particularly of Dr. Franco Lucchesi and Ms. Giusy Cappellotto. We also thank Dr. Elisabetta Fabiani for her valuable help with several aspects of this book. C. Catassi A. Fasano G.R. Corazza
Contents Current understanding of the basis for coeliac disease ............................................ 1 Ludvig M Sollid The identification of toxic T cell stimulatory gluten response peptides early in coeliac disease ................................................................................................... 13 Frits Koning Toxic gluten peptides in coeliac disease identified by in vivo gluten challenge: a single dominant T cell epitope ? ......................................................................... 17 Robert P Anderson Role of A-gliadin 31-49 peptide ........................................................................... 27 27 Paul J Ciclitira The association of the HLA-DQ molecules with coeliac disease in the Saharawi: an evolutionary perspective on coeliac disease .................................... 31 Francesco Cucca, Carlo Catassi Primary prevention of coeliac disease by favourable infant feeding practices ..... 43 Anneli Ivarsson, Lars Åke Persson, Olle Hernell Mechanisms of oral tolerance: lessons for coeliac disease ? ................................ 61 Conleth Feighery Genetically detoxified grains in coeliac disease .................................................... 75 Federico Biagi, Antonio Di Sabatino, Jonia Campanella, Gino Roberto Corazza Immunotherapy of coeliac disease: where do we stand? ....................................... 83 Carmen Gianfrani, Mauro Rossi, Giuseppe Mazzarella, Francesco Maurano, VirginiaSalvati, Delia Zanzi, Salvatore Auricchio, Riccardo Troncone The most recent advances on gluten toxicity in coeliac disease ............................ 89 Gino Roberto Corazza, Carlo Catassi, Alessio Fasano xiii
Page 1: Perspectives on Coeliac Disease Vol
Page 4: The AIC Meeting was held in the Aul
Page 8 and 9: Italian Coeliac Society, Via Picott
Page 11: Preface Coeliac disease (CD) is a u
Page 16 and 17: 2 THE BASIS OF COELIAC DISEASE hapl
Page 18 and 19: 4 THE BASIS OF COELIAC DISEASE 1 pr
Page 20 and 21: 6 THE BASIS OF COELIAC DISEASE spre
Page 22 and 23: 8 THE BASIS OF COELIAC DISEASE Ackn
Page 24 and 25: 10 THE BASIS OF COELIAC DISEASE glu
Page 27 and 28: Catassi C, Fasano A, Corazza GR (ed
Page 29: T CELL RESPONSES TO GLUTEN PEPTIDES
Page 32 and 33: 18 A DOMINANT EPITOPE IN GLUTEN PEP
Page 42 and 43: 28 ROLE OF A-GLIADIN 31-49 PEPTIDE
Page 45 and 46: Catassi C, Fasano A, Corazza GR (ed
Page 47 and 48: COELIAC DISEASE IN THE SAHARAWI 33
Page 55: COELIAC DISEASE IN THE SAHARAWI 41
Page 58 and 59: 44 INFANT FEEDING PRACTICES AND COE
Page 60 and 61: 46 INFANT FEEDING PRACTICES AND COE
Page 62 and 63:
48 INFANT FEEDING PRACTICES AND COE
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Page 66 and 67:
Age (years) 52 INFANT FEEDING PRACT
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Page 70 and 71:
Page 72 and 73:
Page 74 and 75:
Page 76 and 77:
62 MECHANISMS OF ORAL TOLERANCE the
Page 78 and 79:
64 MECHANISMS OF ORAL TOLERANCE pot
Page 80 and 81:
66 MECHANISMS OF ORAL TOLERANCE Epi
Page 82 and 83:
68 MECHANISMS OF ORAL TOLERANCE typ
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70 MECHANISMS OF ORAL TOLERANCE 51
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72 MECHANISMS OF ORAL TOLERANCE 23.
Page 89 and 90:
Catassi C, Fasano A, Corazza GR (ed
Page 91 and 92:
GENETICALLY DETOXIFIED GRAINS 77 to
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• • GENETICALLY DETOXIFIED GRAI
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GENETICALLY DETOXIFIED GRAINS 81 3.
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IMMUNOTHERAPY OF COELIAC DISEASE 85
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IMMUNOTHERAPY OF COELIAC DISEASE 87
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RECENT ADVANCES ON GLUTEN TOXICITY
Page 107 and 108:
Index A Antiendomysium antibodies (
Page 109:
INDEX 95 W Wheat, 7, 23, 27, 31, 53
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