primary prevention of coeliac disease - Associazione Italiana ...

Index
A
Antiendomysium antibodies (EMA), 33-37
Antigen
presenting cells, 3, 17-18, 67
specific T cells, 18, 90
-specific therapies, 17
B
Barley, 1, 23-24, 27, 31, 43, 53, 75, 83
B cell, 17-18, 62
Breast feeding, 46-48
C
Cytokines, 6, 17-19, 68
IL-10, 68, 85-86
interferon gamma (IFNγ), 6, 18, 21, 48,
68, 86
TGF-β1, 48
Th1 associated, 19
Th1-like, 17
tumour necrosis factor (TNF), 6, 18
D
Deamidation, 4-5, 14, 19, 90
Dendritic cells, 17, 67-68
Detoxified grains, 78-79, 89
E
Environmental factors
gut infections, 3
Infant feeding, 45, 52, 54, 56
role of, 36-37, 43
Epidemic of coeliac disease, 44-45, 52, 54
Epitope, 4-7, 14, 22, 24, 84, 90
dominant, 90
hierarchies, 20-21, 90
toxic, 28
Extracellular matrix degeneration, 6
F
Familial clustering, 31-32, 35, 43
G
Genetic predisposition, 36, 61
CTLA4, 2, 83-84
DQ2, 2-4, 6-7, 13, 17, 28, 32, 37, 44, 61,
83, 85
DQ7, 2-3
DQ8, 2-4, 6-7, 13, 28, 32, 44, 61, 83, 85
DR3, 2-3, 35-37
DR4, 2-3
DR5, 2-3
DR7, 2-3
5qter, 2
11qter, 2
Gliadin, 1, 4, 75-77, 91
A-gliadin, 19-23, 25, 27-28, 89
31-49, 28
57-73 QE65, 22-24, 90
57-68, 90
57-89, 90
62-75, 90
deamidation of, 19
epitopes, 84, 90
HLA-DQ2 restricted, 22, 24
fractions, 27-28
toxicity, 28
genes, 90
intranasal administration, 86
peptides, 28, 91
Gluten, 1, 3-4, 6, 17, 43-44, 48, 51, 54, 61,
64, 67, 75
age at introduction of, 49
amount of, 47-49, 54, 56
challenge, 18, 21, 25
-containing cereals
consumption of, 48
genetic modification of, 56
intake, 52
consumption of, 48
deamidation, 4
-derived peptides, 3
epitopes, 4-7, 14
free diet, 7, 17-18, 21, 61, 83
immune tolerance of, 64
in follow-on formula, 48
in the Saharawi's diet, 37
intolerance, 65
native, 90
peptides, 4, 37, 85, 89
deamidation, 5, 13-14
dominant, 90
immune tolerance to, 56
"toxic", 19
33-mer, 90
proteins, 4
high-molecular weight, 76
medium-molecular weight, 76
93