primary prevention of coeliac disease - Associazione Italiana ...

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94 INDEX low-molecular weight, 76 functional properties of, 76 specific response in children, 13 in adults, 14 toxicity, 89 -specific memory T cells, 20 Glutenin, 1, 4, 27, 75-77, 89-90 Gut barrier, 91 H HLA genes - see genetic predisposition I Immunotherapy, 83-88, 90 Infant feeding, 45, 52-54 Insulin dependent diabetes mellitus (IDDM) risk, 44 Intestinal mucosa, 91 Intraepithelial lymphocytes (IELs), 6, 67 γδ, 6 M Mucosal immune response control of, 65-69 system, 63, 66 tolerance, 69-70 N Non-HLA genes, 32, 44 O Oats, 27, 53 Organ culture, 6, 28, 84-85 P Pathophysiology of coeliac disease, 6, 43, 69, 90 Aetiology, 1, 17, 43 multifactorial, 51 Prevalence of coeliac disease, 1, 33 in the general pediatric population, 1, 36 in the Saharawi, 33, 37 in the Sardinians, 37 in family members, 1, 43 Primary prevention, 43, 56, 89 R Risk factors, 31-32 associated, 51 component causal, 51 necessary causal, 51 contributing, 50 infections, 50 socio-economic background, 50 Rye, 1, 23-24, 27, 43, 53, 75 S Saharawi population, 33-37 Small intestinal biopsy, 33, 37 Susceptibility haplotype, 37 T T cell, 2-4, 7, 62, 64. 90 activation, 6, 13, 17, 62, 89-90 antigen specific, 18 CD4, 17-19, 21 CD4+ TCRαβ, 2-3, 6-7 CD8, 17 clones, 5, 14 intestinal, 19, 22 peripheral blood, 19 delayed-type hypersensitivity, 61 DQ2-restricted, 90 epitope, 7, 17, 19 dominant, 24 gliadin-specific, 19 hierarchy, 21 gluten reactive, 3 helper, 67 gliadin-specific, 21 receptor, 17 regulatory, 63, 68, 85 response, 14, 89-90 suppressor, 63 Th1, 83 tolerance, 68 TGF-β, 68 Tissue transglutaminase (tTG), 4, 6-7, 13, 19, 37, 90 activity, 4-5 antibodies, 6-7 Tolerance, 61-63, 90 central, 62 immune, 56, 62 mucosal immune, 69, 86-87 oral, 5, 7, 13, 44, 46, 48, 64-65, 67-68, 70 experimental models of, 65 peripheral, 62 Treated coeliac disease, 18 Twins, 1, 31, 43 V Vaccine, 17, 56, 65, 90
INDEX 95 W Wheat, 7, 23, 27, 31, 53, 75, 83 and gluten, 1 flour proteins, 27 gliadin, 83 protein, 75 genetic of, 77-78 gliadins, 75, 77 glutenins, 75, 77 starch, 27 Z Zonulin, 91
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Perspectives on Coeliac Disease Vol
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The AIC Meeting was held in the Aul
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Italian Coeliac Society, Via Picott
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Preface Coeliac disease (CD) is a u
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Contents Current understanding of t
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2 THE BASIS OF COELIAC DISEASE hapl
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4 THE BASIS OF COELIAC DISEASE 1 pr
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6 THE BASIS OF COELIAC DISEASE spre
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8 THE BASIS OF COELIAC DISEASE Ackn
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10 THE BASIS OF COELIAC DISEASE glu
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Catassi C, Fasano A, Corazza GR (ed
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T CELL RESPONSES TO GLUTEN PEPTIDES
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18 A DOMINANT EPITOPE IN GLUTEN PEP
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28 ROLE OF A-GLIADIN 31-49 PEPTIDE
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Catassi C, Fasano A, Corazza GR (ed
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COELIAC DISEASE IN THE SAHARAWI 33
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Page 58 and 59: 44 INFANT FEEDING PRACTICES AND COE
Page 66 and 67: Age (years) 52 INFANT FEEDING PRACT
Page 76 and 77: 62 MECHANISMS OF ORAL TOLERANCE the
Page 78 and 79: 64 MECHANISMS OF ORAL TOLERANCE pot
Page 80 and 81: 66 MECHANISMS OF ORAL TOLERANCE Epi
Page 82 and 83: 68 MECHANISMS OF ORAL TOLERANCE typ
Page 84 and 85: 70 MECHANISMS OF ORAL TOLERANCE 51
Page 86 and 87: 72 MECHANISMS OF ORAL TOLERANCE 23.
Page 89 and 90: Catassi C, Fasano A, Corazza GR (ed
Page 91 and 92: GENETICALLY DETOXIFIED GRAINS 77 to
Page 93 and 94: • • GENETICALLY DETOXIFIED GRAI
Page 95 and 96: GENETICALLY DETOXIFIED GRAINS 81 3.
Page 99 and 100: IMMUNOTHERAPY OF COELIAC DISEASE 85
Page 101 and 102: IMMUNOTHERAPY OF COELIAC DISEASE 87
Page 105 and 106: RECENT ADVANCES ON GLUTEN TOXICITY
Page 107: Index A Antiendomysium antibodies (
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