Summary of Research Findings

Antioxidant Research (continued)
12. Title
In Vitro Inhibition of Microsomal Lipid Peroxidation by MA-631, Student Rasayana (SR), Ladies Rasayana (LR),
and Maharishi Coffee Substitute (MCS)
Publication
The Pharmacologist, Vol. 34, No. 3, p. 184, 1992 (Abstract).
Authors
H.M. Sharma, A. Hanna, E.M. Kauffman, and H.A.I. Newman.
Conducted at
College of Medicine, The Ohio State University, Columbus, OH 43210
Summary
In this study, the effects of MA-631, SR, LR, and MCS on microsomal lipid peroxidation were examined in
vitro. Rat liver microsomes were incubated with a sodium ascorbate and ADP-iron complex or with an NADPHgenerating
system to stimulate nonenzymatic or enzymatic lipid peroxidation, respectively. Aqueous or alcoholic
extracts of MA-631, SR, LR, and MCS, when added to these incubation systems, inhibited hepatic microsomal
lipid peroxidation in a dose-dependent manner. The alcoholic extracts were the most effective antiperoxidants
in both systems. The alcoholic extract of MCS inhibited ascorbate- or NADPH-induced lipid peroxidation by 56%
and 63%, with 12 micrograms and 22.5 micrograms, respectively. These findings suggest that these Maharishi
Ayur-Veda food supplements may be useful in the treatment of free radical-induced injury due to their antiperoxidant
properties.
Study 12 Research Highlights
In vitro aqueous and alcoholic extracts of MA-631, Student Rasayana, Ladies Rasayana, and Maharishi Coffee
Substitute demonstrated potent antiperoxidant properties in a dose-dependent manner. Thus, these supplements
may be useful in the treatment of free radical-induced injury due to their antiperoxidant properties.
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