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Summary of Research Findings

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Antioxidant <strong>Research</strong> (continued)<br />

13. Title<br />

Maharishi Amrit Kalash [MAK-4 and MAK-5] Rejuvenates Ageing Central Nervous System’s Antioxidant Defense<br />

System: An In Vivo Study<br />

Publication<br />

Pharmacological <strong>Research</strong>, Vol. 40, No. 6, pp 497-502, 1999.<br />

Authors<br />

Bhupinder Pal Singh Vohra,* Satya Prakash Sharma,* and Vinod Kumar Kansal.**<br />

Conducted at<br />

**Laboratory <strong>of</strong> Nutritional Histopathology and Ageing, Department <strong>of</strong> Zoology, Kurukshetra University,<br />

Kurukshetra—136 119, Haryana, India<br />

**Animal Biochemistry Division, National Dairy <strong>Research</strong> Institute, Karnal, Haryana, India<br />

<strong>Summary</strong><br />

The oxygen-free radical involvement in various deteriorative processes and in aging is unquestionably<br />

established. In the present study, age-related changes in antioxidant enzyme activity in the different regions<br />

<strong>of</strong> CNS <strong>of</strong> 10-month and 32-month-old guinea pigs were studied. Maharishi Amrit Kalash has shown promise<br />

in inhibiting the in vitro and in vivo lipid peroxidation. Therefore, in the present study the effect <strong>of</strong> MAK on<br />

the activity <strong>of</strong> antioxidant enzymes was checked. Our results indicate that the activity <strong>of</strong> superoxide dismutase<br />

and glutathione peroxidase, was found to be reduced p

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