Summary of Research Findings
Summary of Research Findings
Summary of Research Findings
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Immunity <strong>Research</strong> (continued)<br />
5. Title<br />
Priming <strong>of</strong> Splenic Lymphocytes After Ingestion <strong>of</strong> an Ayurvedic Herbal Food Supplement [MAK-5]: Evidence for<br />
an Immunomodulatory Effect<br />
Publication<br />
Biochemical Archives, Vol. 6, pp. 267-274, 1990.<br />
Authors<br />
Kottarappat N. Dileepan,* Vimal Patel,** Hari M. Sharma,† and Daniel J. Stechschulte.*<br />
Conducted at<br />
**Division <strong>of</strong> Allergy, Clinical Immunology and Rheumatology, Department <strong>of</strong> Medicine, University <strong>of</strong> Kansas<br />
Medical Center, Kansas City, KS 66103<br />
**Department <strong>of</strong> Pathology, Indiana University School <strong>of</strong> Medicine, Indianapolis, IN 46223<br />
† Department <strong>of</strong> Pathology, Ohio State University College <strong>of</strong> Medicine, Columbus, OH 43210<br />
<strong>Summary</strong><br />
The in vivo immunomodulatory effects <strong>of</strong> an Ayurvedic<br />
food supplement (Maharishi Amrit Kalash Ambrosia, MAK-5)<br />
were studied in rats gavaged with this preparation at a<br />
dose <strong>of</strong> 50 mg/day for 10 or 20 days. After these regimens,<br />
mitogen-induced lymphocyte proliferation, macrophage<br />
superoxide anion production, and phagocytosis were assayed.<br />
In vitro lymphoproliferative responses to various mitogens<br />
were markedly enhanced by MAK-5 ingestion. MAK-5-<br />
mediated increases in stimulation indices ranged from 32-88%<br />
for varying concentrations <strong>of</strong> phytohemagglutinin (PHA).<br />
MAK-5 treatment did not affect spontaneous lymphocyte<br />
proliferation. The lymphoproliferative response induced by<br />
MAK-5 ingestion was significant even in animals treated for 10<br />
days and persisted for at least 15 days after discontinuation <strong>of</strong><br />
MAK-5. Macrophage superoxide anion generation and phagocytosis<br />
were unaltered as a result <strong>of</strong> MAK-5 treatment. These<br />
data indicate that ingestion <strong>of</strong> this food supplement enhances<br />
lymphocyte responsiveness to mitogens without affecting<br />
spontaneous proliferation.<br />
Study 5 <strong>Research</strong> Highlights<br />
As evaluated in mice, MAK-5 enhances lymphocyte<br />
responsiveness to mitogens without affecting spontaneous<br />
proliferation.<br />
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