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Summary of Research Findings

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<strong>Research</strong> on Anti-Aging, Neurophysiology and Intelligence (continued)<br />

Maharishi Amrit Kalash [MAK-4 and MAK-5]<br />

Publication<br />

Federation <strong>of</strong> American Societies for Experimental Biology Journal, Vol. 5, No. 6, p. A1735, 1991 (Abstract).<br />

Authors<br />

J.Z. Fields, E. Eftekhari, J.F. Hagen, L.J. Wichlinski, and R.H. Schneider (SPON: A.H. Friedman).<br />

Conducted at<br />

<strong>Research</strong> Service 151, VA Hosp., Hines, IL 60141<br />

Dept. <strong>of</strong> Pharmacology, Loyola Univ. Med. Sch., Maywood, IL<br />

Dept. <strong>of</strong> Physiology, Maharishi International University, Fairfield, IA<br />

<strong>Summary</strong><br />

MAK is an herbal preparation available as a food supplement. It is being taken for its anticipated healthpromoting<br />

and anti-aging benefits. MAK refers to the combination <strong>of</strong> two natural products: M4 a paste, and M5<br />

a tablet. Combined, MAK is comprised <strong>of</strong> plants or plant parts from 24 different herbs. Sharma et al. (Pharmacol<br />

Biochem Behav, 35:767–773, 1990) showed that MAK prevents and even reverses chemically induced breast<br />

tumors in rats. We showed (JZ Fields et al, The Pharmacologist, 32:155, 1990) that aqueous extracts <strong>of</strong> MAK<br />

scavenged both OFR (superoxide) and non-radical oxidants (hypochlorous acid) in suspensions <strong>of</strong> human neutrophils<br />

without compromising the viability <strong>of</strong> the cells. In mice (C57BL/6 male, n=29/group) fed 6% MAK in<br />

the diet starting at 18 months <strong>of</strong> age, 80% <strong>of</strong> MAK mice were alive at 23 mo vs. 48% for controls (p

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