Summary of Research Findings

Cardiovascular Research (continued)
10. Title
In-Vitro Inhibition of Microsomal Lipid Peroxidation by MA-631, Student and Ladies Rasayana (SR and LR) and
Maharishi Coffee Substitute (MCS)
Publication
The Pharmacologist, Vol. 34, No. 3, p. 184, 1992 (Abstract).
Authors
H.M. Sharma, A. Hanna, E.M. Kauffman, and H.A.I. Newman (SPON: D. Feller).
Conducted at
College of Medicine, The Ohio State University, Columbus, OH 43210
Summary
MCS, MA-631, M-4, and M-5 have been shown to inhibit in-vitro human LDL oxidation. In the present study,
the effects of MA-631, SR, LR and MCS on microsomal lipid peroxidation were examined in vitro. Rat liver
microsomes were incubated with a sodium ascorbate and ADP-iron complex or with an NADPH generating system
to stimulate non-enzymatic or enzymatic lipid peroxidation respectively. Aqueous or alcoholic extracts of
MA-631, SR, LR and MCS, when added to these incubation systems, inhibited hepatic microsomal lipid peroxidation
in a dose dependent manner. The alcoholic extracts were the most effective antiperoxidants in both systems.
Alcoholic extract of MCS inhibited ascorbate or NADPH-induced lipid peroxidation by 56% and 63% with
12 ugm and 22.5 ugm, respectively. These findings suggest that these Maharishi Ayurveda food supplements
may be useful in the treatment of free radical induced injury due to their antiperoxidant properties.
Study 10 Research Highlights
In vitro aqueous and alcoholic extracts of MA-631, Student Rasayana, Ladies Rasayana, and Maharishi Coffee
Substitute demonstrated potent antiperoxidant properties in a dose-dependent manner. Thus, these supplements
may be useful in the treatment of free radical-induced injury due to their antiperoxidant properties.
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