Summary of Research Findings

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Cancer Research 1. Title Antineoplastic Properties of Maharishi-4 [MAK-4] Against DMBA-Induced Mammary Tumors in Rats Publication Pharmacology, Biochemistry and Behavior, Vol. 35, pp. 767-773, 1990. Authors Hari M. Sharma,* Chandradhar Dwivedi,** Bryan C. Satter,** Krishnamurthy P. Gudehithlu,* Hussein Abou- Issa,* William Malarkey,* and Gopi A. Tejwani.* Conducted at **College of Medicine, The Ohio State University, Columbus OH 43210 **College of Pharmacy, South Dakota State University, Brookings, SD 57007 Summary The herbal mixture MAK-4 (Maharishi Amrit Kalash-4) was tested for anticarcinogenic and anticancer properties against 7,12–dimethylbenz(a)anthracene (DMBA)-induced mammary tumors in rats. The 6% MAK- 4-supplemented diet protected against DMBA-induced carcinogenesis by reducing both tumor incidence and multiplicity during initiation and promotion phases. MAK-4 provided up to 88% protection (p
Cancer Research (continued) 2. Title Antineoplastic Properties of Maharishi Amrit Kalash [MAK-5], An Ayurvedic Food Supplement, Against 7,12- Dimethylbenz(a)anthracene-Induced Mammary Tumors in Rats Publication Journal of Research and Education in Indian Medicine, Vol. 10, No. 3, pp. 1-8, July-September 1991. Authors Hari M. Sharma,* Chandradhar Dwivedi,** Bryan C. Satter,** and Hussein Abou-Issa.* Conducted at **College of Medicine, The Ohio State University, Columbus, OH 43210 **College of Pharmacy, South Dakota State University, Brookings, SD 57007 Summary The herbal mixture Maharishi Amrit Kalash-5 (MAK-5) was tested for antineoplastic properties against 7,12-dimethylbenz(a)anthracene (DMBA)- induced mammary tumors in rats. The 0.2% (w/w) MAK-5-supplemented diet protected against DMBA-induced carcinogenesis during the promotion phase by reducing both tumor incidence and multiplicity. MAK-5 provided up to 62.5% protection (p
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