(log ppb) HPRT VF (x 10
(log ppb) HPRT VF (x 10
(log ppb) HPRT VF (x 10
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Glutathion-S-Transferasen<br />
(GSH-Transferasen)<br />
• Glutathione (GSH)<br />
• Reacts non-enzymatically<br />
• Substrates<br />
– Hydrophobic<br />
– Electrophilic<br />
• Catalyzed enzymatically<br />
• Glutathione-S-transferases<br />
– 5-<strong>10</strong>% of cellular protein<br />
Conjugates excreted<br />
-in bile (large conjugates)<br />
-in urine as mercapturic acids (small, converted conjugates)