(log ppb) HPRT VF (x 10
(log ppb) HPRT VF (x 10
(log ppb) HPRT VF (x 10
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Genetic Polymorphisms<br />
Toxicant Susceptibility<br />
DNA Sequence Variation lead to:<br />
• Amino acid substitutions<br />
• Catalytic<br />
• Stability<br />
• Genomic deletions<br />
• Loss of Function<br />
• Regulatory differences<br />
• Altered transcription