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Glutathion-S-Transferasen<br />

(GSH-Transferasen)<br />

Papilloma nach DMBA Verabreichung:<br />

Einfluss von Glutathiontransferase<br />

Fig. 5. Tumor incidence of papillomas in mice treated with DMBA and TPA. Susceptibility of the mice to the<br />

tumorigenic effects of DMBA was determined by using the initiation-promotion protocol outlined in Material and<br />

Methods. After treatment, GstP1/P2(/) and GstP1/P2(+/+) mice were scored for papilloma numbers on a<br />

weekly basis, and statistical analysis was carried out by using the Statview software package (Abacus Concepts,<br />

Berkeley, CA). a = P < 0.0001, b = P < 0.001.<br />

Henderson et al, PNAS 1998

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