(log ppb) HPRT VF (x 10
(log ppb) HPRT VF (x 10
(log ppb) HPRT VF (x 10
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Metabolism Studies:<br />
Liver in vitro metabolism systems<br />
Metabolic stability<br />
Metabolic profiling<br />
Kinetics<br />
Drug-drug<br />
interactions<br />
Induction studies<br />
Metabolism tool for in<br />
vitro endpoint tests<br />
Applications of in vitro liver systems<br />
Slices<br />
+<br />
+<br />
±<br />
±<br />
+<br />
±<br />
Hepatocyte<br />
s<br />
+<br />
+<br />
+<br />
+<br />
+<br />
±<br />
Liver in vitro system<br />
Cell<br />
lines<br />
-<br />
-<br />
±<br />
±<br />
Subcellular<br />
fractions<br />
Modified according to Guillouzo A (1998) Environmental Health Perspectives <strong>10</strong>6(2), 511-532.<br />
Pelkonen O et al. (2004) Basic & Clinical Pharmaco<strong>log</strong>y & Toxico<strong>log</strong>y 96, 167-175.<br />
-<br />
±<br />
+<br />
±<br />
+<br />
+<br />
-<br />
±<br />
Genetically<br />
engineered<br />
cells<br />
-<br />
±<br />
-<br />
±<br />
-<br />
±
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