(log ppb) HPRT VF (x 10

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Ethanol • Ethanol • Widely consumed • Induces (increases) the expression of CYP2E1 • Acetaminophen (Tylenol) • Widely used pain reliever • Toxified by CYP2E1? What are the possible consequences? What are the possible solutions?
Differential Sensitivity • Gender Differences • Alcohol Dehydrogenase Men tolerate ethanol “better” than women WHY?
Page 1 and 2:
TOXICOLOGY Introductory Course Dr.
Page 3 and 4:
Fremdstoffe im Körper Das “Lipop
Page 5 and 6:
Enzymsysteme Lipophiler Fremdstoff
Page 7 and 8:
Leber als Hauptorgan des Fremdstoff
Page 9 and 10:
FUNKTIONALISIERUNG
Page 11 and 12:
Cytochrom P450 R-H + O 2 + NADPH +
Page 13 and 14:
Cytochrom P450 CYP450 Class CYP1 CY
Page 15 and 16:
Cytochrom P450 Oxidative Desalkylie
Page 17 and 18:
Cytochrom P450 • Cytochrome P450
Page 19 and 20: Cytochrom P450 Benzo[a]pyrene HC CH
Page 21 and 22: Cytochrom P450 N-Hydroxylierung aro
Page 23 and 24: Cytochrom P450 TAKE HOME MESSAGE CY
Page 25 and 26: MAO Inhibitors • 5-Hydroxytryptam
Page 27 and 28: Flavin monooxygenase • Flavoprote
Page 29 and 30: Alkoholdehydrogenase (ADH)
Page 31 and 32: Aldehyddehydrogenase (ALDH)
Page 33 and 34: Andere nicht-CYP Oxidationen Prosta
Page 35 and 36: Reduktion • von Halogen-Alkanen d
Page 37 and 38: Reduktion
Page 39 and 40: hoch lipophil, metabolisch stabil A
Page 41 and 42: Glucuronidierung UDP-Glucuronosyltr
Page 43 and 44: Glucuronidierung UDP-Glucuronosyltr
Page 45 and 46: Sulfatierung “Sulfatierung” - S
Page 47 and 48: Acetylierung Acetylierung ist als P
Page 49 and 50: Acetylierung N-Acetyltransferasen D
Page 51 and 52: Methylierung � Methylierung ist k
Page 53 and 54: Glutathion-S-Transferasen (GSH-Tran
Page 59 and 60: Zusammenfassung Konjugation Reaktio
Page 61 and 62: • “Phase III” biotransformati
Page 63 and 64: Polymorphismus Polymorphismus: Schn
Page 65 and 66: AhR-Mediated Induction of Biotransf
Page 67 and 68: Metabolische Aktivierung (Giftung)
Page 69: Ethanol • Overlap in specificity
Page 73 and 74: Ethnic Differences Genetic Polymorp
Page 75 and 76: Dimethylbenzanthracene Aktivierung
Page 77 and 78: Benzo[a]pyren CYP: Oxidation von po
Page 79 and 80: Aromatische Amine: Aminobiphenyl Me
Page 81 and 82: Aromatische Amine Polymorphismus: S
Page 83 and 84: Butadien • BD monomer, styrene-BD
Page 85 and 86: Butadien • Conjugation to GSH •
Page 87 and 88: Evolutionary Biotransformation Vert
Page 89 and 90: Genetic Polymorphisms Toxicant Susc
Page 91 and 92: Differential Sensitivity • Gender
Page 93 and 94: Metabolism Studies: Liver in vitro
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(log ppb) HPRT VF (x 10

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