ANNUAL REPORT 2012 - TiGenix

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Title Country Application number Use of CXCL6 chemokine in the prevention or repair of cartilage defects (PCT Publication WO2005/014026) (Continued) Marker genes for use in the identification of chondrocyte phenotypic stability and in the screening of factors influencing cartilage production. (PCT Publication WO2008/061804) Biopsy Device (PCT Publication WO/2010/092100) B. TiGenix Trademark Portfolio JP NO NZ RU SG JP522,851/2006 NO20060464 NZ545,702 RU2006107536 SG18893 US US 10/595,072 US-CIP1 US EP AU CA CN HK IN IL JP NZ NO RU SG US12/345,369 US12/515488 EP07846847 AU2007324705 CA2670419 CN200780043440 HK1136964 2830/DELNP/2009 IL198794 JP2009-537561 NZ576330 NO20091571 RU2009123960 SG200903163 AU 2010212842 CA CN CA2752797 CN201080012848.6 EA 201101177 EP 10707483.3 IL 214630 IN JP IN6375/DELNP/2011 JP549550/11 US 13/201686 The table below provides an overview of TiGenix’s registered trademark and registration pending trademark applications. Registered trademarks are highlighted in white. Country Trademark Classes Europe (CTM) CELLERIX 5, 10 & 42 Spain RETROFECT 35 Europe (CTM) IDRYON 10 Europe (CTM) ONTARIL 5 Europe (CTM) MIREDAL 5 Europe (CTM) LIVING MEDICINES 16 & 35 Europe (CTM) CELLERIX LIVING MEDICINES 5, 10 & 42 Europe (CTM) ALOCELLIX 3 & 5 Europe (CTM) ADICELL-X 3 & 5 Europe (CTM) CELLERIX (Graphic) 5, 10 & 42 Europe (CTM) ALOFISEL 3 & 5 208 TiGenix I annual report 2012
Country Trademark Classes USA CELLERIX (Graphic) 5 & 42 USA ONTARIL 5 USA CELLERIX LIVING MEDICINES 5 & 42 Austria 5, 10 & 42 Benelux 5, 10 & 42 Canada 5, 10 & 42 Denmark 5, 10 & 42 Finland 5, 10 & 42 France 5, 10 & 42 ChondroCelect Germany 5, 10 & 42 Italy 5, 10 & 42 Norway 5, 10 & 42 Spain 5, 10 & 42 Sweden 5, 10 & 42 Switzerland 5, 10 & 42 United Kingdom 5, 10 & 42 United States 5, 10 & 42 Austria 5 & 42 Benelux 5, 10, 41 & 42 Canada 5 & 42 Croatia 5 & 42 Denmark 5 & 42 Finland 5 & 42 France 5 & 42 TiGenix Germany 5 & 42 Italy 5 & 42 Norway 5 & 42 Spain 5 & 42 Sweden 5 & 42 Switzerland 5 & 42 United Kingdom 5 & 42 United States 1 & 5 ChondroBoost Benelux 5, 10 & 42 CCI Benelux 5, 10 & 42 US 1, 5, 10, 42 & 45 MeniscoCelect Europe (CTM) 5, 10 & 42 US 1, 5, 10, 42 & 45 Benelux 5, 10 & 44 CCH US 10, 44 & 42 Canada 5, 10 & 42 Europe (CTM) 5, 10 & 42 209
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ANNUAL REPORT 2012
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9. MAJOR SHAREHOLDERS 103 9.1. OVER
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There can be no assurance that TiGe
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educing their ultimate value to the
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eimbursement in certain instances s
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or the relevant manufacturing proce
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In recent years, it expanded its op
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making this change may be costly an
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TiGenix’s development stage produ
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qualified employees and consultants
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1. Introduction Annual report 2012
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2. Persons Responsible for the Cont
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4. Selected Financial Information Y
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5.3. ORGANISATIONAL STRUCTURE TiGen
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Date Transaction Number and class o
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Date Transaction Number and class o
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(12) The shares were subscribed to
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5.5. DESCRIPTION OF RIGHTS AND BENE
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Formalities to attend the sharehold
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amendments to the Articles of Assoc
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the existing shareholders have a pr
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Issue date Term Number of warrants
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6. Business Overview Most of the in
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6.2. COMPETITIVE STRENGTHS The Comp
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6.3. IMPORTANT EVENTS IN THE DEVELO
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6.3.5. Funding history Since its in
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non-weight bearing area of the join
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6.4.5. Commercial launch ChondroCel
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und Behandlungsmethode”) in sever
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Therapeutics (product Hyalograft C)
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Different routes of administration
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Clinical development In January 201
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evenues from this pipeline within t
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that the average cost of treatment
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TiGenix has obtained cGMP status fo
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Biologics for treatment of Rheumato
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of the patents and patent applicati
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- “Marker genes for use in the id
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manufacturing process and therapeut
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Invalidation of US patent US6777231
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7. Corporate Governance 7.1. GENERA
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7.2.3. Independent directors As to
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7.2.4. Composition of the Board of
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of Ravago NV, Vanbreda Risk & Benef
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Litigation statement concerning the
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As proof of the independence and an
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for their healthcare and biotechnol
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7.5. SCIENTIFIC ADVISORY BOARD AND
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As of the date of publication of th
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(rounded down to the nearest intege
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usiness at customary market conditi
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9. Major Shareholders 9.1. OVERVIEW
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10. Financial Statements : General
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11. Consolidated Financial Statemen
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11.3. CONSOLIDATED STATEMENT OF CAS
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The consolidated financial statemen
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11.5.2.2. Basis of consolidation Th
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are provided and costs are incurred
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of interest on the remaining balanc
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Deferred tax assets and liabilities
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- Partnering of Cx601 (i.e. finding
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The Group is mainly exposed to the
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fiscal year 2010, reference is made
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Sales and marketing expenses Years
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The number of employees in the R&D
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Analysis of profit/(loss) for the p
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(8) Disposal group held for sale Th
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(10) Property, plant and equipment
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The decrease of stock in 2012 compa
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dividends will be based upon the Co
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alance. As a consequence, the Compa
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(23) Other current liabilities The
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TiGenix SAU - Stock options Prior t
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(25) Business combination Descripti
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(26) Related party transactions Tra
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(28) Commitments and contingencies
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(30) Consolidation scope Name Subsi
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We believe that the audit evidence
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Page 161 and 162: 12.2. STATUTORY BALANCE SHEET 2010-
Page 163 and 164: The value of receivables is reduced
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Page 167 and 168: 2013. The facility will provide the
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Page 171 and 172: Operating result (EBIT) and net res
Page 173 and 174: Statement of financial position The
Page 175 and 176: - The total personnel costs of EUR
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Page 179 and 180: continue as a going concern and to
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Page 187 and 188: Shares and warrants held by indepen
Page 189 and 190: - Long-term incentive plan : warran
Page 191 and 192: Shares and warrants held by executi
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Page 195 and 196: actual bonus equal to 78 % of her p
Page 197 and 198: was reduced to a half-time role com
Page 199 and 200: 14. Business and Financial Update a
Page 201 and 202: Financial results for the full year
Page 203 and 204: 15. Available Documents The Company
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