Software application manual - VTP UP

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Chapter 6To view the method properties associated with the file, highlight any plot and select Explore> Show > Show File Information (or press Ctrl-I on the keyboard). Analyst displays aconsiderable amount of property data for the file, including a section for Software ApplicationProperties. This section displays the Coulochem III method properties, as shown in Figure6.6.Figure 6.6. Coulochem III Method Properties Displayed in a Data File’sSoftware Application Properties48 Coulochem ® III Analyst Driver – Version 1.0User’s Manual
7. Application Examples7.1 OverviewThis chapter provides examples of the use of the Coulochem III detector to controlelectrochemical (EC) cells with fixed (DC) or dynamic (pulsed) potential waveforms. Cellscan be used as reactors in series upstream of the MS ion source and/or as detectors in parallel(via flow split) with MS. Common applications are for on-line derivatization (e.g., to assistMS ionization, for mass tagging and protein cleavage) and to study the susceptibility ofcompounds to oxidation (or reduction), the nature of products and short-lived intermediates,and the associated reaction pathways. These applications are of interest for generating andcharacterizing products that often correspond to biological metabolites, degradants or reactivespecies of interest. The use of EC in parallel with MS provides complementary, orthogonal,detection with high sensitivity and selectivity for redox active species. Typical applicationsare DC detection of antioxidants and markers of oxidative stress and pulsed detection ofcarbohydrates.Each example tabulates the conditions for the liquid chromatography (LC) setup, CoulochemIII (EC) setup and mass spectrometer (MS) setup.Coulochem ® III Analyst Driver - Version 1.0 49User’s Manual
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Coulochem ® III Analyst ® DriverV
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WarrantyA. ESA Biosciences, Inc. (
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License AgreementESA BIOSCIENCES, I
Page 7 and 8: License AgreementBY CUSTOM OR TRADE
Page 9 and 10: Table of Contents1. Introduction...
Page 11 and 12: 1. Introduction1.1 OverviewThis man
Page 13 and 14: Introductioncursor (over the Auto Z
Page 15 and 16: 2. System Requirements and Installa
Page 17 and 18: System Requirements and Installatio
Page 19 and 20: System Requirements and Installatio
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Page 24 and 25: Chapter 3Figure 3.1. Status Bar Sho
Page 26 and 27: Chapter 33.4 Configuring the Couloc
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Page 31 and 32: Creating and Modifying Acquisition
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Page 56 and 57: Chapter 6Figure 6.4. Acquisition St
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Page 62 and 63: Chapter 7LC Conditions• Column: S
Page 64 and 65: Chapter 7Oxidation at 1000 mV produ
Page 66 and 67: Chapter 7ResultsFigure 7.4 shows th
Page 68 and 69: Appendix AC:\Program Files\ESA Bios
Page 71 and 72: Appendix B: Parameter Ranges and De
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