Software application manual - VTP UP
Software application manual - VTP UP
Software application manual - VTP UP
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Chapter 7Oxidation at 1000 mV produces 3 additional oxidation products (Figure 7.3), with peaks atm/z 299.8 (D), 356.8 (A) and 388.8 (B).cps1.6e+61.4e+61.2e+61.0e+68.0e+56.0e+54.0e+52.0e+50.0EC Potential 1000mVTIC ESI+A0 2 4 6 8 10 12 14BTime (min)CDE120 120120100 A XIC m/z 356.8 100 B XIC m/z 388.8C100 XIC m/z 358.8806040CH3ONCH3806040 CH3ONCH3CH3806040CH3ONHCH32020 OH200100 200 300 400m/z0100200 300 400m/z0100 200 300 400m/z120100D XIC m/z 299.8 E XIC m/z 372.8120100808060OH60ONCH34040CH320CH320CH30100 200 300 400m/z0100 200 300 400m/zFigure 7.3. Tamoxifen at a Cell Potential of 1000 mVThis example demonstrates that the EC oxidation products for a given compound oftencoincide with metabolites observed in biological assays. The Coulochem III Analyst driverallowed for automated analysis of tamoxifen using various EC cell potential. The simplicityand speed of on-line EC-LC-MS often provides an effective means of characterizing some ofthe many unknown metabolites encountered in multivariate profiling studies.54 Coulochem ® III Analyst Driver – Version 1.0User’s Manual